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Systemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma

Authors
 Jihei Sara Lee  ;  Hyoung Won Bae  ;  Sungeun Park  ;  Chan Yun Kim  ;  Sang Yeop Lee 
Citation
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.63(3) : 28, 2022-03 
Journal Title
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN
 0146-0404 
Issue Date
2022-03
MeSH
Aged ; Ankle Brachial Index ; Female ; Glaucoma, Open-Angle* / diagnosis ; Glaucoma, Open-Angle* / pathology ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Nerve Fibers / pathology ; Pulse Wave Analysis ; Retinal Ganglion Cells / pathology ; Vascular Stiffness*
Abstract
Purpose: The purpose was to identify association between systemic arterial stiffness predicted by brachial-ankle pulse wave velocity (PWV) and initial location of structural progression in early open-angle glaucoma.

Methods: Patients with early open-angle glaucoma who underwent PWV measurements were subjected to a retrospective review of medical records. A total of 160 eyes of 160 patients were subjected to analyses. Patients were categorized into three PWV groups. Structural progression was determined using event-based analysis of the Guided Progression Analysis software of Cirrus optical coherence tomography.

Results: Thirty-eight patients had a PWV of 1400 cm/s or less on both the left and right sides (low PWV, 39.5% females, 53.9 ± 8.8 years old), and 46 patients showed a PWV of 1800 cm/s or more on either side (high PWV; 54.3% females, 71.3 ± 5.8 years old). The rest of the patients had an intermediate PWV (n = 76, 50.0% females, 59.8 ± 8.6 years old). Among patients who showed progression in 69.3 ± 41.5 months, macular ganglion cell-inner plexiform layer (mGCIPL) loss preceded peripapillary retinal nerve fiber layer (ppRNFL) loss in 86.7% of high PWV group (n = 15, 60.0% females, 70.0 ± 6.0 years old) in comparison with 26.7% of the low PWV group (P = 0.002). The PWV was significantly higher in patients whose structural progression was first observed at mGCIPL (1744.1 ± 347.7 cm/s) than patients whose initial location was ppRNFL (1452.0 ± 201.0 cm/s; P = 0.012). A high PWV was associated with increased likelihood of structural progression at mGCIPL (odds ratio, 7.484; 95% confidence interval, 1.212-49.196; P = 0.030) among patients who showed progression.

Conclusions: PWV is a significant predictor of the location of structural progression in open-angle glaucoma. Vascular insufficiency may be an important aspect in the pathogenesis of glaucoma.
Files in This Item:
T202201248.pdf Download
DOI
10.1167/iovs.63.3.28
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Park, Sung Eun(박성은)
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
Lee, Jihei Sara(이지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188465
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