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Systemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma

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dc.contributor.author김찬윤-
dc.contributor.author박성은-
dc.contributor.author배형원-
dc.contributor.author이상엽-
dc.contributor.author이지혜-
dc.date.accessioned2022-05-09T17:14:59Z-
dc.date.available2022-05-09T17:14:59Z-
dc.date.issued2022-03-
dc.identifier.issn0146-0404-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188465-
dc.description.abstractPurpose: The purpose was to identify association between systemic arterial stiffness predicted by brachial-ankle pulse wave velocity (PWV) and initial location of structural progression in early open-angle glaucoma. Methods: Patients with early open-angle glaucoma who underwent PWV measurements were subjected to a retrospective review of medical records. A total of 160 eyes of 160 patients were subjected to analyses. Patients were categorized into three PWV groups. Structural progression was determined using event-based analysis of the Guided Progression Analysis software of Cirrus optical coherence tomography. Results: Thirty-eight patients had a PWV of 1400 cm/s or less on both the left and right sides (low PWV, 39.5% females, 53.9 ± 8.8 years old), and 46 patients showed a PWV of 1800 cm/s or more on either side (high PWV; 54.3% females, 71.3 ± 5.8 years old). The rest of the patients had an intermediate PWV (n = 76, 50.0% females, 59.8 ± 8.6 years old). Among patients who showed progression in 69.3 ± 41.5 months, macular ganglion cell-inner plexiform layer (mGCIPL) loss preceded peripapillary retinal nerve fiber layer (ppRNFL) loss in 86.7% of high PWV group (n = 15, 60.0% females, 70.0 ± 6.0 years old) in comparison with 26.7% of the low PWV group (P = 0.002). The PWV was significantly higher in patients whose structural progression was first observed at mGCIPL (1744.1 ± 347.7 cm/s) than patients whose initial location was ppRNFL (1452.0 ± 201.0 cm/s; P = 0.012). A high PWV was associated with increased likelihood of structural progression at mGCIPL (odds ratio, 7.484; 95% confidence interval, 1.212-49.196; P = 0.030) among patients who showed progression. Conclusions: PWV is a significant predictor of the location of structural progression in open-angle glaucoma. Vascular insufficiency may be an important aspect in the pathogenesis of glaucoma.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAssociation For Research In Vision And Ophthalmology (Arvo)-
dc.relation.isPartOfINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAnkle Brachial Index-
dc.subject.MESHFemale-
dc.subject.MESHGlaucoma, Open-Angle* / diagnosis-
dc.subject.MESHGlaucoma, Open-Angle* / pathology-
dc.subject.MESHHumans-
dc.subject.MESHIntraocular Pressure-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNerve Fibers / pathology-
dc.subject.MESHPulse Wave Analysis-
dc.subject.MESHRetinal Ganglion Cells / pathology-
dc.subject.MESHVascular Stiffness*-
dc.titleSystemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorJihei Sara Lee-
dc.contributor.googleauthorHyoung Won Bae-
dc.contributor.googleauthorSungeun Park-
dc.contributor.googleauthorChan Yun Kim-
dc.contributor.googleauthorSang Yeop Lee-
dc.identifier.doi10.1167/iovs.63.3.28-
dc.contributor.localIdA01035-
dc.contributor.localIdA05758-
dc.contributor.localIdA01814-
dc.contributor.localIdA02820-
dc.contributor.localIdA06116-
dc.relation.journalcodeJ01187-
dc.identifier.eissn1552-5783-
dc.identifier.pmid35353125-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.affiliatedAuthor김찬윤-
dc.contributor.affiliatedAuthor박성은-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor이상엽-
dc.contributor.affiliatedAuthor이지혜-
dc.citation.volume63-
dc.citation.number3-
dc.citation.startPage28-
dc.identifier.bibliographicCitationINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.63(3) : 28, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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