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Dosimetric outcomes of preoperative treatment planning with intraoperative optimization using stranded seeds in prostate brachytherapy

 Jason Joon Bock Lee  ;  Eungman Lee  ;  Won Hoon Choi  ;  Jihun Kim  ;  Kyung Hwan Chang  ;  Dong Wook Kim  ;  Han Back Shin  ;  Tae Hyung Kim  ;  Hwa Kyung Byun  ;  Jaeho Cho 
 PLOS ONE, Vol.17(3) : e0265143, 2022-03 
Journal Title
Issue Date
Brachytherapy* / adverse effects ; Humans ; Iodine Radioisotopes / therapeutic use ; Male ; Prostate / surgery ; Prostatic Neoplasms* / drug therapy ; Prostatic Neoplasms* / radiotherapy ; Prostatic Neoplasms* / surgery ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Rectum
This study aimed to evaluate the quality of low-dose-rate (LDR) prostate brachytherapy (BT) based on treatment-related dosimetric outcomes. Data of 100 patients treated using LDR BT with stranded seeds from November 2012 to November 2017 were collected. The prescription dose for the prostate was 145 Gy. The dose constraints for the preoperative plan were: V100% ≥ 95%, V150% ≤ 60%, V200% ≤ 20% for the prostate; V100% for rectum, ≤ 1 cc; and V200 Gy for urethra, 0.0 cc. Intraoperative real-time dose calculation and postoperative dose distribution analysis on days 0 and 30 were performed. Median dosimetric outcomes on days 0 and 30 respective were: V100% 92.28% and 92.23%, V200% 18.63% and 25.02%, and D90% 150.88 Gy and 151.46 Gy for the prostate; V100% for the rectum, 0.11 cc and 0.22 cc; and V200 Gy for the urethra, 0.00 cc and 0.00 cc, respectively. Twenty patients underwent additional seed implantation to compensate for insufficient dose coverage of the prostate. No loss or substantial migration of seeds or severe toxicity was reported. With stranded seed implantation and intraoperative optimization, appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5819-9783
Kim, Jihun(김지훈) ORCID logo https://orcid.org/0000-0003-4856-6305
Kim, Taehyung(김태형)
Byun, Hwa Kyung(변화경) ORCID logo https://orcid.org/0000-0002-8964-6275
Shin, Han-Back(신한백)
Lee, Eung Man(이응만)
Lee, Jason Joon Bock(이준복)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
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