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Sarcopenia increases the risk of major organ or vessel invasion in patients with papillary thyroid cancer

Authors
 Ja Kyung Yoon  ;  Jung Hyun Yoon  ;  Vivian Youngjean Park  ;  Minah Lee  ;  Jin Young Kwak 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 4233, 2022-03 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-03
MeSH
Humans ; Male ; Neoplasm Recurrence, Local / pathology ; Neoplasm Staging ; Neoplastic Processes ; Prognosis ; Retrospective Studies ; Sarcopenia* / pathology ; Thyroid Cancer, Papillary / pathology ; Thyroid Neoplasms* / complications ; Thyroid Neoplasms* / epidemiology ; Thyroid Neoplasms* / surgery ; Thyroidectomy
Abstract
While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear. To investigate the impact of sarcopenia on aggressive clinicopathologic features in PTC patients, prospectively collected data on 305 patients who underwent surgery for PTC with preoperative staging ultrasonography and bioelectrical impedance analysis were retrospectively analyzed. Nine sarcopenia patients with preoperative sarcopenia showed more patients aged 55 or older (p = 0.022), higher male proportion (p < 0.001), lower body-mass index (p = 0.015), higher incidence of major organ or vessel invasion (p = 0.001), higher T stage (p = 0.002), higher TNM stage (p = 0.007), and more tumor recurrence (p = 0.023) compared to the non-sarcopenia patients. Unadjusted and adjusted logistic regression analyses showed that sarcopenia (odds ratio (OR) 9.936, 95% confidence interval (CI) 2.052-48.111, p = 0.004), tumor size (OR 1.048, 95% CI 1.005-1.093, p = 0.027), and tumor multiplicity (OR 3.323, 95% CI 1.048-10.534, p = 0.041) significantly increased the risk of T4 cancer. Sarcopenia patients showed significantly lower disease-free survival probability compared to non-sarcopenia patients. Therefore, preoperative sarcopenia in PTC patients should raise clinical suspicion for a more locally advanced disease and direct appropriate management and careful follow-up.
Files in This Item:
T202200960.pdf Download
DOI
10.1038/s41598-022-08224-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Ja Kyung(윤자경) ORCID logo https://orcid.org/0000-0002-3783-977X
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Lee, Minah(이민아)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188360
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