88 215

Cited 0 times in

Nationwide Survey for Current Status of Laboratory Diagnosis of Clostridioides difficile Infection in Korea

 Hae-Sun Chung  ;  Jeong Su Park  ;  Bo-Moon Shin  ;  Hyeon Mi Yoo  ;  Heejung Kim  ;  Jihyun Cho  ;  Chae Hoon Lee  ;  Nam Hee Ryoo  ;  Jae-Seok Kim  ;  Jae-Woo Chung  ;  Ki Ho Hong  ;  You Sun Kim  ;  Young-Seok Cho 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.37(5) : e38, 2022-02 
Journal Title
Issue Date
Clinical Laboratory Techniques / methods* ; Clostridioides difficile / isolation & purification* ; Clostridium Infections / diagnosis* ; Clostridium Infections / epidemiology* ; Health Surveys Humans ; Population Surveillance ; Republic of Korea
Clostridioides difficile Infection ; Culture ; Glutamate Dehydrogenase ; Laboratory Diagnosis ; Nucleic Acid Amplification Test ; Survey ; Toxin AB Enzyme Immunoassay
Background: The interest in Clostridioides difficile infection (CDI) has increased, and the choice of assays became wider since the first national survey in Korea on CDI diagnosis in 2015. We conducted a survey of the domestic CDI assays with more varied questions to understand the current situation in Korea.

Methods: In April 2018, about 50 questions on the current status of CDI assays and details on implementation and perceptions were written, and a survey questionnaire was administered to laboratory medicine specialists in 200 institutions.

Results: One-hundred and fifty institutions responded to the questionnaire, of which 90 (60.0%) including one commercial laboratory, performed CDI assays. The toxin AB enzyme immunoassay (toxin AB EIA), nucleic acid amplification test (NAAT), and C. difficile culture, glutamate dehydrogenase assay, alone or in combination with other assays, were used in 75 (84.3%), 52 (58.4%), 35 (36.0%), and 23 (25.8%), respectively, and 65 (73.0%) institutions performed a combination of two or more assays. The sensitivity of toxin AB EIA was more negatively perceived, and that on specificity was more positively perceived. The perception of sensitivity and specificity of NAAT was mostly positive. Perception on the algorithm test projected it as useful but in need of countermeasures. Sixty-three (73.3%) institutions responded that they performed surveillance on CDI.

Conclusion: This study provides useful evidence on the current status of CDI laboratory diagnosis in Korea as well as on items that require improvement and is thought to aid in standardizing and improving the CDI laboratory diagnosis in Korea.
Files in This Item:
T202202307.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Hong, Ki Ho(홍기호) ORCID logo https://orcid.org/0000-0002-5700-9036
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.