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단일 기관에서의 수혈관련 급성폐손상 증례보고 및 새로운 진단 기준에 대한 고찰

Other Titles
 Case Series of Transfusion-Related Acute Lung Injury in a Tertiary Hospital and a Practical Comparison with the New Diagnostic Criteria 
Authors
 이광섭  ;  김신영  ;  노주혜  ;  최승준  ;  김현옥 
Citation
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.30(3) : 219-229, 2019-12 
Journal Title
Korean Journal of Blood Transfusion(대한수혈학회지)
ISSN
 1226-9336 
Issue Date
2019-12
Keywords
Transfusion adverse reaction ; Transfusion-related acute lung injury ; Diagnostic criteria
Abstract
Background:
Transfusion-related acute lung injury (TRALI) is defined as acute respiratory distress syndrome with non-cardiogenic pulmonary edema caused by transfusion. It occurs only rarely but could result in patient mortality. TRALI has been declining since the successful adoption of TRALI risk mitigation strategies in several countries. The new diagnostic criteria were suggested in 2019 based on the knowledge and experience gained throughout the last decade. This article integrated a series of TRALI cases diagnosed in a tertiary hospital while reviewing each case based upon the new diagnostic criteria.

Methods:
Among the reported transfusion adverse reactions that occurred from March 2013 to June 2019, seven TRALI cases were recruited for this study. Each case was retrospectively reexamined with its clinical condition and transfusion history. The diagnosed cases were classified into TRALI subtypes newly suggested in the 2019 version.

Results:
The mean time interval to adverse reaction was 117 minutes (range: 7~370 minutes) and all satisfied the condition of hypoxemia and bilateral pulmonary infiltrations. The transfused blood components were apheresis platelets in three cases, platelet concentrates in one case, red blood cells in one case and combinations of different products in two cases. Five cases were diagnosed as possible TRALI, and all five cases were diagnosed as TRALI type 2 (2019 criteria).

Conclusion:
In our center, seven patients were diagnosed TRALI during the last 6 years. Screening more TRALI patients according to the new criteria, along with investigating the patients’ clinical characteristics, transfused blood components, treatments and integrated research, will facilitate Korean research on this field of medicine.
Files in This Item:
T999201976.pdf Download
DOI
10.17945/kjbt.2019.30.3.219
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Roh, Juhye(노주혜)
Lee, Kwang Seob(이광섭) ORCID logo https://orcid.org/0000-0002-6286-108X
Choi, Seung Jun(최승준) ORCID logo https://orcid.org/0000-0003-0736-1055
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188110
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