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Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement

 Ji-Yeong Kim  ;  Woojin Choi  ;  Utkarsh Mangala  ;  Ji-Young Seo  ;  Tae-Yun Kang  ;  Joohee Lee  ;  Taeho Kim  ;  Jung-Yul Cha  ;  Kee-Joon Lee  ;  Kwang-Mahn Kim  ;  Jin-Man Kim  ;  Dohyun Kim  ;  Jae-Sung Kwon  ;  Jinkee Hong  ;  Sung-Hwan Choi 
 BIOACTIVE MATERIALS, Vol.14 : 219-233, 2022-08 
Journal Title
Issue Date
Multivalent network modifier ; Bioactive materials ; Glass polyalkenoate cement ; Ion release ; Remineralization ; Multispecies biofilm resistance
Polyalkenoate cement (PAC) is a promising material for regenerative hard tissue therapy. The ionically rich glass component of PAC encourages bioactive interaction via. the release of essential ions. However, PAC bioactivity is restricted owing to (i) structurally inherent cationic network formers and (ii) surface bacterial biofilm formation. These two factors cause a deficiency in ion release, further complicated by secondary infections and premature therapeutic failure. Here, a multivalent zwitterionic network modifier (mZM) is presented for upregulation of ionic exchange and bioactivity enhancement. By introducing a non-zero charged mZM into PACs, an increase in the proportion of non-bridging oxygen occurs. The network modification promotes ion channel formation, causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite (ca. 74%). Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the mZM. Furthermore, divalent cationic interaction results in bacterial biofilm reduction (ca. 68%) while also influencing a shift in the biofilm species composition, which favors commensal growth. Therefore, PAC modification with mZM offers a promising solution for upregulation of bioactivity, even aiding in customization by targeting site-specific regenerative therapy in future applications.
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2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Tae-Yun(강태윤) ORCID logo https://orcid.org/0000-0003-0447-9605
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Kim, Dohyun(김도현) ORCID logo https://orcid.org/0000-0002-0772-6985
Kim, Ji Young(김지영)
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
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