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Eyedrop vaccination: an immunization route with promises for effective responses to pandemics

Authors
 Jihei Sara Lee  ;  Sangchul Yoon  ;  Soo Jung Han  ;  Eun-Do Kim  ;  Jiyeon Kim  ;  Hae-Sol Shin  ;  Kyoung Yul Seo 
Citation
 EXPERT REVIEW OF VACCINES, Vol.21(1) : 91-101, 2022-01 
Journal Title
EXPERT REVIEW OF VACCINES
ISSN
 1476-0584 
Issue Date
2022-01
Keywords
Eyedrop ; Vaccination ; mucosal vaccination
Abstract
Introduction: Mucosal vaccines have several advantages over parenteral vaccines. They induce both systemic and mucosal antigen-specific immune responses, allow easy administration, and bypass the need for trained medical personnel.

Areas covered: Eye mucosa is a novel route of mucosal vaccine administration. Eyedrop vaccination induces systemic and mucosal immune responses similar to other forms of mucosal vaccines such as oral and intranasal vaccines.

Expert opinion: Eyedrop vaccines are free of serious adverse side effects like the infiltration of CNS by pathogens. Studies over the years have shown promising results for eye drop vaccines against infectious agents like the influenza virus, Salmonella typhi, and Escherichia coli in animal models. Such efficacy and safety of eyedrop vaccination enable the application of eyedrop vaccines against other infectious diseases as well as chronic diseases. In this review of published literature, we examine the mechanism, efficacy, and safety of eyedrop vaccines and contemplate their role in times of a pandemic.
Full Text
https://www.tandfonline.com/doi/abs/10.1080/14760584.2022.2008246
DOI
10.1080/14760584.2022.2008246
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Lee, Jihei Sara(이지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187995
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