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Clinicopathological differences in radiation-induced organizing hematomas of the brain based on type of radiation treatment and primary lesions

Authors
 Myung Sun Kim  ;  Se Hoon Kim  ;  Jong-Hee Chang  ;  Mina Park  ;  Yoon Jin Cha 
Citation
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.56(1) : 16-21, 2022-01 
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
ISSN
 2383-7837 
Issue Date
2022-01
Keywords
Cavernous hemangioma ; Gamma knife surgery ; Latency ; Radiation therapy ; Radiation-induced organizing hematoma
Abstract
Background: Radiation-induced organizing hematoma (RIOH) is a sporadic form of cavernous hemangioma (CH) that occurs after cerebral radiation. RIOH lesions are distinct histologically from de novo CH; however, detailed research on this subject is lacking. In the present study, the clinical and histological features of RIOHs were evaluated based on causative lesions.

Methods: The present study included 37 RIOHs confirmed by surgical excision from January 2009, to May 2020, in Yonsei Severance Hospital. All cases were divided into subgroups based on type of radiation treatment (gamma knife surgery [GKS], n = 24 vs. conventional radiation therapy [RT], n = 13) and pathology of the original lesion (arteriovenous malformation, n = 14; glioma, n = 12; metastasis, n = 4; other tumors, n = 7). The clinicopathological results were compared between the groups.

Results: Clinical data of multiplicity, latency, and size and wall thickness of the original tumors and RIOHs were analyzed. The GKS group showed shorter latency (5.85 ± 4.06 years vs. 11.15 ± 8.27 years, p = .046) and thicker tumor wall (693.7 ± 565.7 μm vs. 406.9 ± 519.7 μm, p = .049) than the conventional RT group. Significant difference was not found based on original pathology.

Conclusions: RIOH is more likely to occur earlier with thick tumor wall in subjects who underwent GKS than in patients who underwent conventional RT. These results indicate the clinical course of RIOH differs based on type of treatment and might help determine the duration of follow-up.
Files in This Item:
T202200320.pdf Download
DOI
10.4132/jptm.2021.08.30
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187952
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