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한국인 포도막흑색종에 대한 임상 경험 및 문헌 고찰

Other Titles
 Uveal Melanoma: A Review of the Literature and Personal Experiences 
Authors
 김용준  ;  이승규  ;  이성철 
Citation
 Journal of Retina, Vol.6(2) : 65-74, 2021-11 
Journal Title
Journal of Retina
ISSN
 2508-1926 
Issue Date
2021-11
Keywords
Brachytherapy ; Metastasis ; Signaling pathway ; Targeted therapy ; Uveal melanoma
Abstract
Uveal melanoma is the most common primary intraocular tumor in adults. The annual incidence rate is approximately 0.42 per million people with an increasing trend in South Korea. Approximately 90% of uveal melanomas occur in the choroid, typically presenting as a dome-shaped mass. Radiotherapy is the mainstay of eye-preserving therapy for primary tumors, and plaque brachytherapy is the most common treatment modality for medium-sized tumors. Although primary tumors respond well to local treatment, systemic metastasis is observed in up to 50% of patients. The most commonly affected organ is the liver. Currently, the underlying mechanism of tumorigenesis and metastasis of the uveal melanoma is poorly understood; there is no effective therapy for metastatic tumors. Recent studies have focused on the oncogenic signaling pathways related to driver mutations in the GNAQ, GNA11, PLCB4, and CYSTLR2 genes. However, most clinical studies applying new targeted therapies failed to improve survival. In this review article, we intend to share clinical experience in Korea, and summarize the latest research on molecular characteristics and targeted therapies for uveal melanoma.
Files in This Item:
T202125268.pdf Download
DOI
10.21561/jor.2021.6.2.65
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Joon(김용준)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187758
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