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한국인 포도막흑색종에 대한 임상 경험 및 문헌 고찰

DC Field Value Language
dc.contributor.author김용준-
dc.contributor.author이승규-
dc.date.accessioned2022-02-23T01:32:21Z-
dc.date.available2022-02-23T01:32:21Z-
dc.date.issued2021-11-
dc.identifier.issn2508-1926-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187758-
dc.description.abstractUveal melanoma is the most common primary intraocular tumor in adults. The annual incidence rate is approximately 0.42 per million people with an increasing trend in South Korea. Approximately 90% of uveal melanomas occur in the choroid, typically presenting as a dome-shaped mass. Radiotherapy is the mainstay of eye-preserving therapy for primary tumors, and plaque brachytherapy is the most common treatment modality for medium-sized tumors. Although primary tumors respond well to local treatment, systemic metastasis is observed in up to 50% of patients. The most commonly affected organ is the liver. Currently, the underlying mechanism of tumorigenesis and metastasis of the uveal melanoma is poorly understood; there is no effective therapy for metastatic tumors. Recent studies have focused on the oncogenic signaling pathways related to driver mutations in the GNAQ, GNA11, PLCB4, and CYSTLR2 genes. However, most clinical studies applying new targeted therapies failed to improve survival. In this review article, we intend to share clinical experience in Korea, and summarize the latest research on molecular characteristics and targeted therapies for uveal melanoma.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean, English-
dc.publisherThe Korean Retina Society-
dc.relation.isPartOfJournal of Retina-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title한국인 포도막흑색종에 대한 임상 경험 및 문헌 고찰-
dc.title.alternativeUveal Melanoma: A Review of the Literature and Personal Experiences-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthor김용준-
dc.contributor.googleauthor이승규-
dc.contributor.googleauthor이성철-
dc.identifier.doi10.21561/jor.2021.6.2.65-
dc.contributor.localIdA05821-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.relation.journalcodeJ03883-
dc.identifier.eissn2508-3589-
dc.subject.keywordBrachytherapy-
dc.subject.keywordMetastasis-
dc.subject.keywordSignaling pathway-
dc.subject.keywordTargeted therapy-
dc.subject.keywordUveal melanoma-
dc.contributor.alternativeNameKim, Yong Joon-
dc.contributor.affiliatedAuthor김용준-
dc.contributor.affiliatedAuthor이승규-
dc.citation.volume6-
dc.citation.number2-
dc.citation.startPage65-
dc.citation.endPage74-
dc.identifier.bibliographicCitationJournal of Retina, Vol.6(2) : 65-74, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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