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Comparative evaluation of Elecsys, Atellica, and Alinity assays for measuring the anti-Hepatitis C virus (HCV) antibody

Authors
 Youn Keong Cho  ;  Sinyoung Kim  ;  Hyun Ok Kim  ;  Da Som Choi  ;  Hyon-Suk Kim  ;  Younhee Park 
Citation
 JOURNAL OF CLINICAL VIROLOGY, Vol.141 : 104910, 2021-08 
Journal Title
JOURNAL OF CLINICAL VIROLOGY
ISSN
 1386-6532 
Issue Date
2021-08
MeSH
Hepacivirus ; Hepatitis C Antibodies* ; Hepatitis C* / diagnosis ; Humans ; Sensitivity and Specificity ; Serologic Tests ; Viremia
Keywords
HCV viremia ; Hepatitis C virus ; anti-HCV assays
Abstract
Background: Hepatitis C virus (HCV) infection is a major cause of liver diseases in Korea. Anti-HCV assays are used to screen for HCV infection. Here, we assessed the agreement and diagnostic performances of three different anti-HCV assays.

Methods: We analyzed 1180 samples using three assay systems-Elecsys Anti-HCV II (Roche Diagnostics), Atellica IM aHCV (Siemens Healthineers), and Alinity s Anti-HCV (Abbott Diagnostics)-and evaluated the agreements between the results and diagnostic performances.

Results: The Cohens kappa coefficients between the Roche and Siemens, Siemens and Abbott, and Roche and Abbott systems were 0.837, 0.961, and 0.849, respectively. The Fleiss kappa coefficient among the three systems was 0.883. The sensitivities and positive predictive values were 86.5 and 89.8 for Roche, 97.5 and 98.1 for Siemens, and 99.4 and 98.2 for Abbott, respectively. The area under the curves of the anti-HCV signal to cutoff (S/Co) ratios or cutoff index for predicting viremia in the Roche, Siemens, and Abbott systems were 0.432, 0.641, and 0.676, respectively; the optimal S/Co ratio was 14.715 for Siemens and 14.42 for Abbott.

Conclusions: All three assays showed excellent diagnostic performance; however, anti-HCV values need to be used with caution to predict viremia; therefore, supplementary tests are necessary to confirm viremia status, especially for samples with low values.
Full Text
https://www.sciencedirect.com/science/article/pii/S1386653221001773?via%3Dihub
DOI
10.1016/j.jcv.2021.104910
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Park, Youn Hee(박윤희) ORCID logo https://orcid.org/0000-0001-8458-1495
Cho, Youn Keong(조윤경) ORCID logo https://orcid.org/0000-0002-7922-0473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187738
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