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Cancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor

Authors
 Hyo-Jin Yoon  ;  Young Shin Chung  ;  Yong Jae Lee  ;  Seung Eun Yu  ;  Sewoom Baek  ;  Hye-Seon Kim  ;  Sang Wun Kim  ;  Jung-Yun Lee  ;  Sunghoon Kim  ;  Hak-Joon Sung 
Citation
 ADVANCED SCIENCE, Vol.8(22) : e2102640, 2021-11 
Journal Title
ADVANCED SCIENCE
ISSN
 * 
Issue Date
2021-11
Keywords
cancer cell-derived nanovesicles ; ovarian cancer ; patient-specific treatments ; self-homing nano-targeting ; tissueoid
Abstract
The current paradigm of cancer medicine focuses on patient- and/or cancer-specific treatments, which has led to continuous progress in the development of patient representatives (e.g., organoids) and cancer-targeting carriers for drug screening. As breakthrough concepts, i) living cancer tissues convey intact profiles of patient-specific microenvironmental signatures. ii) The growth mechanisms of cancer mass with intense cell-cell interactions can be harnessed to develop self-homing nano-targeting by using cancer cell-derived nanovesicles (CaNVs). Hence, a tissueoid model of ovarian cancer (OC) is developed by culturing OC patient tissues in a 3D gel chip, whose microchannel networks enable perfusion to maintain tissue viability. A novel model of systemic cancer responses is approached by xenografting OC tissueoids into ischaemic hindlimbs in nude mice. CaNVs are produced to carry general chemotherapeutics or new drugs under pre/clinical studies that target the BRCA mutation or energy metabolism, thereby increasing the test scope. This pioneer study cross-validates drug responses from the OC clinic, tissueoid, and animal model by demonstrating the alignment of results in drug type-specific efficiency, BRCA mutation-dependent drug efficiency, and metabolism inhibition-based anti-cancer effects. Hence, this study provides a directional foundation to accelerate the discovery of patient-specific drugs with CaNV application towards future precision medicine.
Files in This Item:
T202125003.pdf Download
DOI
10.1002/advs.202102640
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Yu, Seung Eun(유승은)
Yoon, Hyo-Jin(윤효진)
Lee, Yong Jae(이용재) ORCID logo https://orcid.org/0000-0003-0297-3116
Lee, Jung-Yun(이정윤) ORCID logo https://orcid.org/0000-0001-7948-1350
Chung, Young Shin(정영신)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187644
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