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Cancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor

DC Field Value Language
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author성학준-
dc.contributor.author윤효진-
dc.contributor.author이용재-
dc.contributor.author이정윤-
dc.contributor.author정영신-
dc.contributor.author유승은-
dc.date.accessioned2022-02-23T01:20:24Z-
dc.date.available2022-02-23T01:20:24Z-
dc.date.issued2021-11-
dc.identifier.issn*-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187644-
dc.description.abstractThe current paradigm of cancer medicine focuses on patient- and/or cancer-specific treatments, which has led to continuous progress in the development of patient representatives (e.g., organoids) and cancer-targeting carriers for drug screening. As breakthrough concepts, i) living cancer tissues convey intact profiles of patient-specific microenvironmental signatures. ii) The growth mechanisms of cancer mass with intense cell-cell interactions can be harnessed to develop self-homing nano-targeting by using cancer cell-derived nanovesicles (CaNVs). Hence, a tissueoid model of ovarian cancer (OC) is developed by culturing OC patient tissues in a 3D gel chip, whose microchannel networks enable perfusion to maintain tissue viability. A novel model of systemic cancer responses is approached by xenografting OC tissueoids into ischaemic hindlimbs in nude mice. CaNVs are produced to carry general chemotherapeutics or new drugs under pre/clinical studies that target the BRCA mutation or energy metabolism, thereby increasing the test scope. This pioneer study cross-validates drug responses from the OC clinic, tissueoid, and animal model by demonstrating the alignment of results in drug type-specific efficiency, BRCA mutation-dependent drug efficiency, and metabolism inhibition-based anti-cancer effects. Hence, this study provides a directional foundation to accelerate the discovery of patient-specific drugs with CaNV application towards future precision medicine.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherWILEY-VCH-
dc.relation.isPartOfADVANCED SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorHyo-Jin Yoon-
dc.contributor.googleauthorYoung Shin Chung-
dc.contributor.googleauthorYong Jae Lee-
dc.contributor.googleauthorSeung Eun Yu-
dc.contributor.googleauthorSewoom Baek-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorJung-Yun Lee-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1002/advs.202102640-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA01958-
dc.contributor.localIdA06078-
dc.contributor.localIdA05165-
dc.contributor.localIdA04638-
dc.contributor.localIdA04849-
dc.relation.journalcodeJ04017-
dc.identifier.eissn2198-3844-
dc.identifier.pmid34664430-
dc.subject.keywordcancer cell-derived nanovesicles-
dc.subject.keywordovarian cancer-
dc.subject.keywordpatient-specific treatments-
dc.subject.keywordself-homing nano-targeting-
dc.subject.keywordtissueoid-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.affiliatedAuthor김상운-
dc.contributor.affiliatedAuthor김성훈-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor윤효진-
dc.contributor.affiliatedAuthor이용재-
dc.contributor.affiliatedAuthor이정윤-
dc.contributor.affiliatedAuthor정영신-
dc.citation.volume8-
dc.citation.number22-
dc.citation.startPagee2102640-
dc.identifier.bibliographicCitationADVANCED SCIENCE, Vol.8(22) : e2102640, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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