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Interaction of CSF α-synuclein and amyloid beta in cognition and cortical atrophy

 Young-Gun Lee  ;  Seun Jeon  ;  Sung Woo Kang  ;  Mincheol Park  ;  Kyoungwon Baik  ;  Han Soo Yoo  ;  Seok Jong Chung  ;  Seong Ho Jeong  ;  Jin Ho Jung  ;  Phil Hyu Lee  ;  Young Ho Sohn  ;  Alan C Evans  ;  Byoung Seok Ye 
 Alzheimer's & dementia, Vol.13(1) : e12177, 2021-05 
Journal Title
Alzheimer's & Dementia
Issue Date
Alzheimer's disease ; Lewy body disease ; cerebrospinal fluid biomarkers ; polygenic risk score ; α‐synuclein
Introduction: Lewy body-related pathology is commonly observed at autopsy in individuals with dementia, but in vivo biomarkers for α-synucleinopathy are lacking.

Methods: Baseline cerebrospinal fluid (CSF) biomarkers, polygenic risk score (PRS) for Parkinson's disease (PRS-PD) and Alzheimer's disease (PRS-AD), longitudinal cognitive scores, and magnetic resonance imaging were measured in 217 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear mixed models were used to find the relationship of CSF biomarkers and the PRS with cognition and cortical atrophy.

Results: Higher PRS-PD and PRS-AD were associated with lower CSF α-synuclein and amyloid beta (Aβ), respectively. Lower CSF α-synuclein and the interaction of CSF α-synuclein and Aβ were associated with lower cognitive scores and global cortical atrophy most prominently in the occipital cortex.

Discussion: Lower CSF α-synuclein could be a biomarker for α-synucleinopathy, and the simultaneous evaluation of CSF biomarkers for AD and CSF α-synuclein could reveal the independent and interactive effects on cognition and cortical atrophy.
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Park, Mincheol(박민철)
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Young-Gun(이영건)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Jeon, Seun(전세운)
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
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