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Low Toe–Brachial Index Is Associated With Stroke Outcome Despite Normal Ankle–Brachial Index

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dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author이일형-
dc.contributor.author이형우-
dc.contributor.author이혜선-
dc.contributor.author허준녕-
dc.date.accessioned2021-12-31T01:19:04Z-
dc.date.available2021-12-31T01:19:04Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187346-
dc.description.abstractIntroduction: We investigated whether the toe–brachial index (TBI) is associated with stroke prognosis and evaluated this association in patients with normal ankle–brachial index (ABI). Methods: Acute ischemic stroke patients who underwent TBI measurements were enrolled. Poor functional outcome was defined as modified Rankin Scale score ≥3. Major adverse cardiovascular event (MACE) was defined as stroke recurrence, myocardial infarction, or death. Normal ABI was defined as 0.9 ≤ ABI ≤ 1.4. Results: A total of 1,697 patients were enrolled and followed up for a median 39.7 (interquartile range, 25.7–54.6) months. During the period, 305 patients suffered MACE (18.0%), including 171 (10.1%) stroke recurrences. TBI was associated with hypertension, diabetes, atrial fibrillation, aortic plaque score, ABI, and brachial–ankle pulse wave velocity (all p < 0.05). In multivariable logistic regression, TBI was inversely associated with poor functional outcome in all patients [odds ratio (OR) 0.294, 95% confidence interval (CI) 0.114–0.759], even in patients with normal ABI (OR 0.293, 95% CI 0.095–0.906). In multivariable Cox regression, TBI < 0.6 was associated with stroke recurrence [hazard ratio (HR) 1.651, 95% CI 1.135–2.400], all-cause mortality (HR 2.105, 95% CI 1.343–3.298), and MACE (HR 1.838, 95% CI 1.396–2.419) in all patients. TBI < 0.6 was also associated with stroke recurrence (HR 1.681, 95% CI 1.080–2.618), all-cause mortality (HR 2.075, 95% CI 1.180–3.651), and MACE (HR 1.619, 95% CI 1.149–2.281) in patients with normal ABI. Conclusions: Low TBI is independently associated with poor short- and long-term outcomes in acute ischemic stroke patients despite normal ABI.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLow Toe–Brachial Index Is Associated With Stroke Outcome Despite Normal Ankle–Brachial Index-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinho Han-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorIlhyung Lee-
dc.contributor.googleauthorHyungwoo Lee-
dc.contributor.googleauthorJoonnyung Heo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.3389/fneur.2021.754258-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA06182-
dc.contributor.localIdA05394-
dc.contributor.localIdA03312-
dc.contributor.localIdA06115-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor이일형-
dc.contributor.affiliatedAuthor이형우-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor허준녕-
dc.citation.volume12-
dc.citation.number754258-
dc.citation.startPage754258-
dc.identifier.bibliographicCitationFRONTIERS IN NEUROLOGY, Vol.12(754258) : 754258, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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