Cited 1 times in
Low Toe–Brachial Index Is Associated With Stroke Outcome Despite Normal Ankle–Brachial Index
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 이일형 | - |
dc.contributor.author | 이형우 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허준녕 | - |
dc.date.accessioned | 2021-12-31T01:19:04Z | - |
dc.date.available | 2021-12-31T01:19:04Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187346 | - |
dc.description.abstract | Introduction: We investigated whether the toe–brachial index (TBI) is associated with stroke prognosis and evaluated this association in patients with normal ankle–brachial index (ABI). Methods: Acute ischemic stroke patients who underwent TBI measurements were enrolled. Poor functional outcome was defined as modified Rankin Scale score ≥3. Major adverse cardiovascular event (MACE) was defined as stroke recurrence, myocardial infarction, or death. Normal ABI was defined as 0.9 ≤ ABI ≤ 1.4. Results: A total of 1,697 patients were enrolled and followed up for a median 39.7 (interquartile range, 25.7–54.6) months. During the period, 305 patients suffered MACE (18.0%), including 171 (10.1%) stroke recurrences. TBI was associated with hypertension, diabetes, atrial fibrillation, aortic plaque score, ABI, and brachial–ankle pulse wave velocity (all p < 0.05). In multivariable logistic regression, TBI was inversely associated with poor functional outcome in all patients [odds ratio (OR) 0.294, 95% confidence interval (CI) 0.114–0.759], even in patients with normal ABI (OR 0.293, 95% CI 0.095–0.906). In multivariable Cox regression, TBI < 0.6 was associated with stroke recurrence [hazard ratio (HR) 1.651, 95% CI 1.135–2.400], all-cause mortality (HR 2.105, 95% CI 1.343–3.298), and MACE (HR 1.838, 95% CI 1.396–2.419) in all patients. TBI < 0.6 was also associated with stroke recurrence (HR 1.681, 95% CI 1.080–2.618), all-cause mortality (HR 2.075, 95% CI 1.180–3.651), and MACE (HR 1.619, 95% CI 1.149–2.281) in patients with normal ABI. Conclusions: Low TBI is independently associated with poor short- and long-term outcomes in acute ischemic stroke patients despite normal ABI. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Low Toe–Brachial Index Is Associated With Stroke Outcome Despite Normal Ankle–Brachial Index | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Minho Han | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Ilhyung Lee | - |
dc.contributor.googleauthor | Hyungwoo Lee | - |
dc.contributor.googleauthor | Joonnyung Heo | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.identifier.doi | 10.3389/fneur.2021.754258 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A06182 | - |
dc.contributor.localId | A05394 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A06115 | - |
dc.relation.journalcode | J02996 | - |
dc.identifier.eissn | 1664-2295 | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | 김영대 | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.contributor.affiliatedAuthor | 이일형 | - |
dc.contributor.affiliatedAuthor | 이형우 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 허준녕 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 754258 | - |
dc.citation.startPage | 754258 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, Vol.12(754258) : 754258, 2021-12 | - |
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