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Effect of rapid fluid administration on the prognosis of septic shock patients with isolated hyperlactatemia: A prospective multicenter observational study

Authors
 Heekyung Lee  ;  Sung-Hyuk Choi  ;  Kyuseok Kim  ;  Tae Gun Shin  ;  Yoo Seok Park  ;  Seung Mok Ryoo  ;  Gil Joon Suh  ;  Woon Yong Kwon  ;  Tae Ho Lim  ;  Donghee Son  ;  Won Young Kim  ;  Byuk Sung Ko 
Citation
 JOURNAL OF CRITICAL CARE, Vol.66 : 154-159, 2021-12 
Journal Title
JOURNAL OF CRITICAL CARE
ISSN
 0883-9441 
Issue Date
2021-12
MeSH
Fluid Therapy ; Humans ; Hyperlactatemia* ; Intensive Care Units ; Prognosis ; Prospective Studies ; Shock, Septic* / therapy
Keywords
Fluid resuscitation ; Hyperlactatemia ; Mortality ; Septic shock
Abstract
Background: We aimed to investigate the association between initial fluid resuscitation in septic shock patients with isolated hyperlactatemia and outcomes.

Methods: This multicenter prospective study was conducted using the data from the Korean Shock Society registry. Patients diagnosed with isolated hyperlactatemia between October 2015 and December 2018 were included and divided into those who received 30 mL/kg of fluid within 3 or 6 h and those who did not receive. The primary outcome was in-hospital mortality; the secondary outcomes were intensive care unit (ICU) admission, length of ICU stay, mechanical ventilation, and renal replacement therapy (RRT).

Results: A total of 608 patients were included in our analysis. The administration of 30 mL/kg crystalloid within 3 or 6 h was not significantly associated with in-hospital mortality in multivariable logistic regression analysis ([OR, 0.8; 95% CI, 0.52-1.23, p = 0.31], [OR, 0.96; 95% CI, 0.59-1.57, p = 0.88], respectively). The administration of 30 mL/kg crystalloid within 3-h was not significantly associated with mechanical ventilation and RRT ([OR, 1.19; 95% CI, 0.77-1.84, p = 0.44], [OR, 1.2; 95% CI, 0.7-2.04, p = 0.5], respectively). However, the administration of 30 mL/kg crystalloid within 6 h was associated with higher ICU admission and RRT ([OR, 1.57; 95% CI, 1.07-2.28, p = 0.02], [OR, 2.08; 95% CI, 1.19-3.66, p = 0.01], respectively).

Conclusions: Initial fluid resuscitation of 30 mL/kg within 3 or 6 h was neither associated with an increased or decreased in-hospital mortality in septic shock patients with isolated hyperlactatemia.
Full Text
https://www.sciencedirect.com/science/article/pii/S0883944121001428
DOI
10.1016/j.jcrc.2021.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Park, Yoo Seok(박유석) ORCID logo https://orcid.org/0000-0003-1543-4664
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187328
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