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Lymphovascular Invasion: Traditional but Vital and Sensible Prognostic Factor in Early Gastric Cancer

Authors
 Seohee Choi  ;  Jeong Ho Song  ;  Sejin Lee  ;  Minah Cho  ;  Yoo Min Kim  ;  Hyoung-Il Kim  ;  Woo Jin Hyung 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.28(13) : 8928-8935, 2021-12 
Journal Title
ANNALS OF SURGICAL ONCOLOGY
ISSN
 1068-9265 
Issue Date
2021-12
MeSH
Humans ; Neoplasm Invasiveness / pathology ; Neoplasm Recurrence, Local / pathology ; Neoplasm Recurrence, Local / surgery ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Stomach Neoplasms* / pathology ; Stomach Neoplasms* / surgery
Abstract
Background: Although patients with early gastric cancer have good prognosis, recurrence after treatment may occur. Lymphovascular invasion (LVI) in gastric cancer has long been suggested as a poor prognostic indicator. This study sought to evaluate the prognostic effect of LVI in patients with early gastric cancer.

Methods: From 2005 to 2016, 6516 patients with early gastric cancer who underwent radical gastrectomy were analyzed. The patients were categorized according to LVI and lymph node (LN) status.

Results: LVI was present in 853 patients (13.1%). Patients with LVI or LN metastasis had more aggressive tumor characteristics than patients without both LVI and LN metastasis. The overall and relapse-free survival in patients with LVI were significantly worse than in patients without LVI. When we compared the survival rate of patients stratified by LVI and LN status, there was a significant overall and relapse-free survival difference between patients without both LVI and LN metastasis compared with those with LVI but without LN metastasis (p < 0.001). The overall and relapse-free survival of patients with LVI but without LN metastasis were similar to those without LVI but with LN metastasis (p = 0.818). Patients with LVI or LN metastasis showed a high frequency of recurrence (p < 0.001). Multivariate analysis showed that LVI and LN status were independent risk factors for relapse-free survival of early gastric cancer patients.

Conclusions: Early gastric cancer with LVI is associated with poor prognosis and frequent recurrence. When predicting the prognosis of patients with early gastric cancer, LVI should be considered.
Full Text
https://link.springer.com/article/10.1245%2Fs10434-021-10224-6
DOI
10.1245/s10434-021-10224-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoo Min(김유민)
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Song, Jeong Ho(송정호)
Lee, Sejin(이세진)
Cho, Minah(조민아) ORCID logo https://orcid.org/0000-0003-3011-5813
Choi, Seo Hee(최서희)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187252
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