53 91

Cited 0 times in

Positive nodal status is still a risk factor for long-term survivors of non-small cell lung cancer 5 years after complete resection

Authors
 Young Ho Yang  ;  Ha Eun Kim  ;  Byung Jo Park  ;  Seokkee Lee  ;  Seong Yong Park  ;  Chang Young Lee  ;  Dae Joon Kim  ;  Hyo Chae Paik  ;  Jin Gu Lee 
Citation
 JOURNAL OF THORACIC DISEASE, Vol.13(10) : 5826-5834, 2021-10 
Journal Title
JOURNAL OF THORACIC DISEASE
ISSN
 2072-1439 
Issue Date
2021-10
Keywords
5-year disease-free survival ; N stage ; Non-small cell lung cancer (NSCLC) ; late recurrence ; risk factor
Abstract
Background: Lung cancer has a poor prognosis; the number of long-term survivors (LTSs) is small compared with that of other cancers. Few studies have focused on late recurrence in LTSs with lung cancer. The purpose of this study was to analyze the risk factors for survival and late recurrence in LTSs after disease-free period of 5 years.

Methods: A retrospective analysis of patients with a disease-free survival of at least 5 years after surgical resection for non-small cell lung cancer (NSCLC) between January 1998 and December 2012 was conducted. Patients who underwent neo-adjuvant therapy, had an incomplete resection, or had advanced stage (stages IIIb and IV) cancer were excluded.

Results: A total of 1,254 (53.2%) of 2,357 patients were enrolled. Of these, 759 (60.5%) were men, and the mean patient age was 61.9±10.1 (range, 10-87 years) years. Pathologic N0 (997 patients, 79.5%) and stage I (860 patients, 68.6%) were the dominant stages. Late recurrence occurred in 22 patients (1.8%) 5 years postoperatively. On multivariate analysis, male sex, older age, node-positive status, and late recurrence were found to be independent risk factors for overall survival (OS), while a node-positive status was the only independent risk factor for disease-free survival [hazard ratio (HR) =3.824; P=0.002; 95% confidence interval (CI): 1.658-8.821].

Conclusions: The nodal stage at the time of surgical resection was found to be an independent risk factor for both OS and disease-free survival 5 years after initial treatment in patients with completely resected NSCLC.
Files in This Item:
T202105307.pdf Download
DOI
10.21037/jtd-21-854
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Kim, Ha Eun(김하은)
Park, Byung Jo(박병조)
Park, Seong Yong(박성용) ORCID logo https://orcid.org/0000-0002-5180-3853
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Yang, Young Ho(양영호)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187220
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links