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Positive nodal status is still a risk factor for long-term survivors of non-small cell lung cancer 5 years after complete resection

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dc.contributor.author김대준-
dc.contributor.author김하은-
dc.contributor.author박병조-
dc.contributor.author박성용-
dc.contributor.author백효채-
dc.contributor.author양영호-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.date.accessioned2021-12-28T17:40:48Z-
dc.date.available2021-12-28T17:40:48Z-
dc.date.issued2021-10-
dc.identifier.issn2072-1439-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187220-
dc.description.abstractBackground: Lung cancer has a poor prognosis; the number of long-term survivors (LTSs) is small compared with that of other cancers. Few studies have focused on late recurrence in LTSs with lung cancer. The purpose of this study was to analyze the risk factors for survival and late recurrence in LTSs after disease-free period of 5 years. Methods: A retrospective analysis of patients with a disease-free survival of at least 5 years after surgical resection for non-small cell lung cancer (NSCLC) between January 1998 and December 2012 was conducted. Patients who underwent neo-adjuvant therapy, had an incomplete resection, or had advanced stage (stages IIIb and IV) cancer were excluded. Results: A total of 1,254 (53.2%) of 2,357 patients were enrolled. Of these, 759 (60.5%) were men, and the mean patient age was 61.9±10.1 (range, 10-87 years) years. Pathologic N0 (997 patients, 79.5%) and stage I (860 patients, 68.6%) were the dominant stages. Late recurrence occurred in 22 patients (1.8%) 5 years postoperatively. On multivariate analysis, male sex, older age, node-positive status, and late recurrence were found to be independent risk factors for overall survival (OS), while a node-positive status was the only independent risk factor for disease-free survival [hazard ratio (HR) =3.824; P=0.002; 95% confidence interval (CI): 1.658-8.821]. Conclusions: The nodal stage at the time of surgical resection was found to be an independent risk factor for both OS and disease-free survival 5 years after initial treatment in patients with completely resected NSCLC.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPioneer Bioscience Pub. Co.-
dc.relation.isPartOfJOURNAL OF THORACIC DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePositive nodal status is still a risk factor for long-term survivors of non-small cell lung cancer 5 years after complete resection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorYoung Ho Yang-
dc.contributor.googleauthorHa Eun Kim-
dc.contributor.googleauthorByung Jo Park-
dc.contributor.googleauthorSeokkee Lee-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorHyo Chae Paik-
dc.contributor.googleauthorJin Gu Lee-
dc.identifier.doi10.21037/jtd-21-854-
dc.contributor.localIdA00368-
dc.contributor.localIdA06134-
dc.contributor.localIdA06090-
dc.contributor.localIdA01508-
dc.contributor.localIdA01846-
dc.contributor.localIdA05762-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.relation.journalcodeJ01907-
dc.identifier.eissn2077-6624-
dc.identifier.pmid34795931-
dc.subject.keyword5-year disease-free survival-
dc.subject.keywordN stage-
dc.subject.keywordNon-small cell lung cancer (NSCLC)-
dc.subject.keywordlate recurrence-
dc.subject.keywordrisk factor-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.affiliatedAuthor김대준-
dc.contributor.affiliatedAuthor김하은-
dc.contributor.affiliatedAuthor박병조-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor백효채-
dc.contributor.affiliatedAuthor양영호-
dc.contributor.affiliatedAuthor이진구-
dc.contributor.affiliatedAuthor이창영-
dc.citation.volume13-
dc.citation.number10-
dc.citation.startPage5826-
dc.citation.endPage5834-
dc.identifier.bibliographicCitationJOURNAL OF THORACIC DISEASE, Vol.13(10) : 5826-5834, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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