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Quantitative MRI Assessment of Pancreatic Steatosis Using Proton Density Fat Fraction in Pediatric Obesity

 Jisoo Kim  ;  Salman S Albakheet  ;  Kyunghwa Han  ;  Haesung Yoon  ;  Mi-Jung Lee  ;  Hong Koh  ;  Seung Kim  ;  Junghwan Suh  ;  Seok Joo Han  ;  Kyong Ihn  ;  Hyun Joo Shin 
 KOREAN JOURNAL OF RADIOLOGY, Vol.22(11) : 1886-1893, 2021-11 
Journal Title
Issue Date
Child ; Female ; Humans ; Liver ; Magnetic Resonance Imaging ; Male ; Non-alcoholic Fatty Liver Disease* / diagnostic imaging ; Pediatric Obesity* / diagnostic imaging ; Protons ; Retrospective Studies
Child ; Fatty liver ; Magnetic resonance imaging ; Obesity ; Pancreas
Objective: To assess the feasibility of quantitatively assessing pancreatic steatosis using magnetic resonance imaging (MRI) and its correlation with obesity and metabolic risk factors in pediatric patients.

Materials and methods: Pediatric patients (≤ 18 years) who underwent liver fat quantification MRI between January 2016 and June 2019 were retrospectively included and divided into the obesity and control groups. Pancreatic proton density fat fraction (P-PDFF) was measured as the average value for three circular regions of interest (ROIs) drawn in the pancreatic head, body, and tail. Age, weight, laboratory results, and mean liver MRI values including liver PDFF (L-PDFF), stiffness on MR elastography, and T2* values were assessed for their correlation with P-PDFF using linear regression analysis. The associations between P-PDFF and metabolic risk factors, including obesity, hypertension, diabetes mellitus (DM), and dyslipidemia, were assessed using logistic regression analysis.

Results: A total of 172 patients (male:female = 125:47; mean ± standard deviation [SD], 13.2 ± 3.1 years) were included. The mean P-PDFF was significantly higher in the obesity group than in the control group (mean ± SD, 4.2 ± 2.5% vs. 3.4 ± 2.4%; p = 0.037). L-PDFF and liver stiffness values showed no significant correlation with P-PDFF (p = 0.235 and p = 0.567, respectively). P-PDFF was significantly associated with obesity (odds ratio 1.146, 95% confidence interval 1.006-1.307, p = 0.041), but there was no significant association with hypertension, DM, and dyslipidemia.

Conclusion: MRI can be used to quantitatively measure pancreatic steatosis in children. P-PDFF is significantly associated with obesity in pediatric patients.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Seung(김승) ORCID logo https://orcid.org/0000-0003-4373-9828
Kim, Jisoo(김지수)
Suh, Junghwan(서정환) ORCID logo https://orcid.org/0000-0002-2092-2585
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Yoon, Haesung(윤혜성) ORCID logo https://orcid.org/0000-0003-0581-8656
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
Ihn, Kyong(인경) ORCID logo https://orcid.org/0000-0002-6161-0078
Han, Kyung Hwa(한경화)
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
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