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The Effect of Adalimumab in Korean Patients with Refractory Noninfectious Uveitis

 Sung Eun Park  ;  Jae Won Jun  ;  Dong Hyun Lee  ;  Sung Chul Lee  ;  Min Kim 
 YONSEI MEDICAL JOURNAL, Vol.62(2) : 177-181, 2021-02 
Journal Title
Issue Date
Adalimumab / administration & dosage ; Adalimumab / adverse effects ; Adalimumab / therapeutic use* ; Adolescent ; Adult ; Female ; Humans ; Immunosuppressive Agents / pharmacology ; Immunosuppressive Agents / therapeutic use ; Male ; Middle Aged ; Republic of Korea ; Retrospective Studies ; Treatment Outcome ; Uveitis / diagnosis ; Uveitis / drug therapy* ; Uveitis / physiopathology ; Visual Acuity / drug effects ; Young Adult
Uveitis ; adalimumab ; inflammation ; macular edema
We sought to analyze the efficacy of adalimumab in active noninfectious uveitis, and evaluate its efficacy and safety for the management of refractory noninfectious uveitis in Korean patients. A retrospective observational study was conducted. A total of 23 eyes of 14 Korean patients with noninfectious uveitis refractory to conventional treatment, including corticosteroid and immunosuppressive agents, were treated with adalimumab between December 2017 and February 2020. The primary outcomes were vitreous haziness grades, anterior chamber cell grades, and central macular thickness measured prior to injection and at 1, 3, 6, and 12 months after the first adalimumab injection. Among the 23 eyes, 14 eyes (60.9%) were diagnosed with panuveitis and 9 eyes (39.1%) with posterior uveitis [mean follow-up period: 22.3 months (7-27)]. The most common etiologic diagnoses requiring adalimumab injection were Behçet's disease (9 eyes, 39.1%), followed by undifferentiated inflammation (6 eyes, 26.1%), Vogt-Koyanagi-Harada disease (3 eyes, 13.0%), psoriasis (2 eyes, 8.7%), serpiginous chorioretinopathy (2 eyes, 8.7%), and systemic lupus erythematosus (1 eye, 4.3%). At the 1-year follow-up after the first injection, anterior chamber cell grade decreased from 0.5±0.4 to 0.3±0.4, and vitreous haziness grade decreased from 1.1±1.1 to 0.3±0.5 (p<0.05). Central macular thickness improved from 347.2±98.1 μm to 264.3±61.1 μm (p<0.05). Adalimumab injection in patients with refractory noninfectious uveitis decreased the anterior chamber cell grade, vitreous haziness grade, and central macular thickness with no severe side effect. Overall, adalimumab injection may, therefore, be an effective and relatively safe treatment modality for noninfectious uveitis in Korean patients.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Park, Sung Eun(박성은)
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