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Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease

Authors
 Jin Ho Jung  ;  Seun Jeon  ;  Kyoungwon Baik  ;  Yang Hyun Lee  ;  Seok Jong Chung  ;  Han Soo Yoo  ;  Seong Ho Jeong  ;  Young H Sohn  ;  Phil Hyu Lee  ;  Byoung Seok Y 
Citation
 NEUROBIOLOGY OF AGING, Vol.106 : 45-54, 2021-10 
Journal Title
NEUROBIOLOGY OF AGING
ISSN
 0197-4580 
Issue Date
2021-10
Keywords
Alzheimer's disease ; Apolipoprotein E ; Cognition ; Lewy body disease ; Mixed dementia ; β-amyloid
Abstract
The role of apolipoprotein E4 (APOE4) in the risk of Alzheimer's disease (AD) and Lewy body disease (LBD), and their relationship with β-amyloid deposition and cognitive dysfunction, remain unclear. Using amyloid and dopamine transporter imaging, we enrolled 126 controls and 208 patients with typical AD (pure AD and Lewy body variant of AD), AD with dementia with Lewy bodies, or typical LBD (dementia with Lewy bodies with amyloid deposition and pure LBD). APOE4 was associated with an increased risk of all disease subtypes except pure LBD. APOE4 was associated with increased frontal β-amyloid burden, and typical LBD was associated with increased occipital β-amyloid levels through its interaction with APOE4. APOE4 was associated with deteriorated general cognition and memory dysfunction via its interaction with typical LBD and AD, respectively. In conclusion, the impact of APOE4 on disease risk depends on its effects on β-amyloid deposition, and APOE4 is associated with β-amyloid deposition regardless of the clinical diagnosis. However, it interacts with typical LBD to cause occipital β-amyloid deposition.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458021001949
DOI
10.1016/j.neurobiolaging.2021.06.004
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Jeon, Seun(전세운)
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187016
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