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Application of hiPSCs in tooth regeneration via cellular modulation

Authors
 Han Ngoc Mai  ;  Eun-Jung Kim  ;  Han-Sung Jung 
Citation
 JOURNAL OF ORAL BIOSCIENCES, Vol.63(3) : 225-231, 2021-09 
Journal Title
JOURNAL OF ORAL BIOSCIENCES
ISSN
 1349-0079 
Issue Date
2021-09
MeSH
Cell Differentiation ; Cell Lineage ; Humans ; Induced Pluripotent Stem Cells* ; Regeneration ; Tissue Engineering
Keywords
Cellular modulation ; Culture system ; Embryonic development ; Regeneration ; hiPSC
Abstract
Background: Induced pluripotent stem cell (iPSC)-based technology provides limitless resources for customized development of organs without any ethical concerns. In theory, iPSCs generated from terminally differentiated cells can be induced to further differentiate into all types of organs that are derived from the embryonic germ layers. Since iPSC reprogramming technology is relatively new, extensive efforts by the researchers have been put together to optimize the protocols to establish in vitro differentiation of human iPSCs (hiPSCs) into various desirable cell types/organs.

Highlights: In the present study, we review the potential application of iPSCs as an efficient alternative to primary cells for modulating signal molecules. Furthermore, an efficient culture system that promotes the differentiation of cell lineages and tissue formation has been reviewed. We also summarize the recent studies wherein tissue engineering of the three germ layers has been explored. Particularly, we focus on the current research strategies for iPSC-based tooth regeneration via molecular modulation.

Conclusion: In recent decades, robust knowledge regarding the hiPSC-based regenerative therapy has been accumulated, especially focusing on cellular modulation. This review provides the optimization of the procedures designed to regenerate specific organs.
Full Text
https://www.sciencedirect.com/science/article/pii/S1349007921000578
DOI
10.1016/j.job.2021.05.002
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186990
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