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Detection of Malignant Melanoma by Tc-99m-HMPAO

Authors
 Young Hoon Ryu  ;  Tae Sub Chung  ;  Jong Doo Lee  ;  Jung Ho Suh  ;  Jong Tae Lee  ;  Chang Yun Park 
Citation
 CLINICAL NUCLEAR MEDICINE, Vol.20(6) : 528-530, 1995-06 
Journal Title
CLINICAL NUCLEAR MEDICINE
ISSN
 0363-9762 
Issue Date
1995-06
MeSH
Aged ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Melanoma / diagnostic imaging* ; Middle Aged ; Neoplasms / diagnostic imaging* ; Organotechnetium Compounds* ; Oximes* ; Technetium Tc 99m Exametazime ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
Abstract
A number of radiopharmaceutical agents have been evaluated for the detection of malignant melanoma. Because anamine is necessary for melanin synthesis, melanotic tumors may possess numerous amine receptors. Tc-99m HMPAO consists of macrocyclic amine radicals. The purpose of this study was to evaluate Tc-99m HMPAO as an effective agent for localizing malignant melanomas on the radioisotope imaging. Six patients, with malignant melanomas were studied. Tc-99m HMPAO SPECT images were obtained in all patients. SPECT was used for the localization of the primary focus, and whole body scans were used for the evaluation of unexpected metastatic lesions. The results were compared with MRI and CT. Tc-99m HMPAO SPECT revealed a high correlation with CT and MRI for the primary focus. Abnormally increased activity at the unexpected metastatic lymph nodes in two patients were also noticed. This was confirmed by CT and MRI for those sites. Tc-99m HMPAO appears to be a useful agent for the localization of both the primary focus and unexpected metastatic lesion in patients with malignant melanoma.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=ovft&AN=00003072-199506000-00014&PDF=y
DOI
10.1097/00003072-199506000-00014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
Chung, Tae Sub(정태섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186536
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