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위암의 DNA 배수성과 휴지기 세포 분획의 임상 및 병리적 연관성

Other Titles
 The clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma 
Authors
 하현수  ;  노성훈  ;  이정운  ;  민진식 
Citation
 Korean Journal of Gastroenterology, Vol.27(5) : 536-545, 1995-05 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
ISSN
 1598-9992 
Issue Date
1995-05
Keywords
Gastric cancer ; Flow cytometry ; DNA ploidy ; S-phase fraction
Abstract
Background/Aims: Previous studies have shown that clinicopathological findings are correlated with the DNA ploidy and S-phase fraction analyzed by flow cytometry in malignant tumors such as breast and colorectal cancer. We studied the clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma. Methods: DNA flow cytometry was performed using fresh tissue in 188 patients who underwent gastrectomy from Aug. 1993 to Feb. 1995. The DNA ploidy and S-phase fraction were correlated with various clinicopathological findings in a retrospective manner. Results: The incidence of DNA aneuploid was 31.9%. DNA aneuploidy was more frequently associated with male patients and with antral location(p=0.001 & p=0.04). Moderately differentiated adenocarcinoma had a significantly higher frequency of DNA aneuploid than the other histologic type(p=0.007). The overall mean of S-phase fraction was 10.0%, The mean for diploid group was 6.3 fo and that for aneuploid group 17.6%. Higher S-phase fraction(-- 11%) was associated with aneuploid, antral location, moderately differentiated adenocarcinoma, and the group with more than 4 metastatic lymph nodes. Conclusions: DNA aneuploidy and S-phase fraction of gastric carcinoma were significantly correlated with various clinicopathological findings. Further studies on correlations with 1ong-term results such as recurrence and survival rate will be required to establish DNA aneuploidy and S-phase fraction as a significant biological marker in gastric carcinoma
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186427
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