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위암의 DNA 배수성과 휴지기 세포 분획의 임상 및 병리적 연관성
DC Field | Value | Language |
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dc.contributor.author | 노성훈 | - |
dc.date.accessioned | 2021-12-27T17:09:29Z | - |
dc.date.available | 2021-12-27T17:09:29Z | - |
dc.date.issued | 1995-05 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186427 | - |
dc.description.abstract | Background/Aims: Previous studies have shown that clinicopathological findings are correlated with the DNA ploidy and S-phase fraction analyzed by flow cytometry in malignant tumors such as breast and colorectal cancer. We studied the clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma. Methods: DNA flow cytometry was performed using fresh tissue in 188 patients who underwent gastrectomy from Aug. 1993 to Feb. 1995. The DNA ploidy and S-phase fraction were correlated with various clinicopathological findings in a retrospective manner. Results: The incidence of DNA aneuploid was 31.9%. DNA aneuploidy was more frequently associated with male patients and with antral location(p=0.001 & p=0.04). Moderately differentiated adenocarcinoma had a significantly higher frequency of DNA aneuploid than the other histologic type(p=0.007). The overall mean of S-phase fraction was 10.0%, The mean for diploid group was 6.3 fo and that for aneuploid group 17.6%. Higher S-phase fraction(-- 11%) was associated with aneuploid, antral location, moderately differentiated adenocarcinoma, and the group with more than 4 metastatic lymph nodes. Conclusions: DNA aneuploidy and S-phase fraction of gastric carcinoma were significantly correlated with various clinicopathological findings. Further studies on correlations with 1ong-term results such as recurrence and survival rate will be required to establish DNA aneuploidy and S-phase fraction as a significant biological marker in gastric carcinoma | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 위암의 DNA 배수성과 휴지기 세포 분획의 임상 및 병리적 연관성 | - |
dc.title.alternative | The clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | 하현수 | - |
dc.contributor.googleauthor | 노성훈 | - |
dc.contributor.googleauthor | 이정운 | - |
dc.contributor.googleauthor | 민진식 | - |
dc.contributor.localId | A01281 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Flow cytometry | - |
dc.subject.keyword | DNA ploidy | - |
dc.subject.keyword | S-phase fraction | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 536 | - |
dc.citation.endPage | 545 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.27(5) : 536-545, 1995-05 | - |
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