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위암의 DNA 배수성과 휴지기 세포 분획의 임상 및 병리적 연관성

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dc.contributor.author노성훈-
dc.date.accessioned2021-12-27T17:09:29Z-
dc.date.available2021-12-27T17:09:29Z-
dc.date.issued1995-05-
dc.identifier.issn1598-9992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186427-
dc.description.abstractBackground/Aims: Previous studies have shown that clinicopathological findings are correlated with the DNA ploidy and S-phase fraction analyzed by flow cytometry in malignant tumors such as breast and colorectal cancer. We studied the clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma. Methods: DNA flow cytometry was performed using fresh tissue in 188 patients who underwent gastrectomy from Aug. 1993 to Feb. 1995. The DNA ploidy and S-phase fraction were correlated with various clinicopathological findings in a retrospective manner. Results: The incidence of DNA aneuploid was 31.9%. DNA aneuploidy was more frequently associated with male patients and with antral location(p=0.001 & p=0.04). Moderately differentiated adenocarcinoma had a significantly higher frequency of DNA aneuploid than the other histologic type(p=0.007). The overall mean of S-phase fraction was 10.0%, The mean for diploid group was 6.3 fo and that for aneuploid group 17.6%. Higher S-phase fraction(-- 11%) was associated with aneuploid, antral location, moderately differentiated adenocarcinoma, and the group with more than 4 metastatic lymph nodes. Conclusions: DNA aneuploidy and S-phase fraction of gastric carcinoma were significantly correlated with various clinicopathological findings. Further studies on correlations with 1ong-term results such as recurrence and survival rate will be required to establish DNA aneuploidy and S-phase fraction as a significant biological marker in gastric carcinoma-
dc.description.statementOfResponsibilityopen-
dc.languageKorean Journal of Gastroenterology-
dc.publisherKorean Journal of Gastroenterology-
dc.relation.isPartOfKorean Journal of Gastroenterology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title위암의 DNA 배수성과 휴지기 세포 분획의 임상 및 병리적 연관성-
dc.title.alternativeThe clinicopathological correlations of DNA ploidy and S-phase fraction in gastric carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthor하현수-
dc.contributor.googleauthor노성훈-
dc.contributor.googleauthor이정운-
dc.contributor.googleauthor민진식-
dc.contributor.localIdA01281-
dc.relation.journalcodeJ02015-
dc.identifier.eissn2233-6869-
dc.subject.keywordGastric cancer-
dc.subject.keywordFlow cytometry-
dc.subject.keywordDNA ploidy-
dc.subject.keywordS-phase fraction-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.affiliatedAuthor노성훈-
dc.citation.volume27-
dc.citation.number5-
dc.citation.startPage536-
dc.citation.endPage545-
dc.identifier.bibliographicCitationKorean Journal of Gastroenterology, Vol.27(5) : 536-545, 1995-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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