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The association between urinary bisphenol A levels and nonalcoholic fatty liver disease in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017

Authors
 Sang Joon An  ;  Eun-Jung Yang  ;  Subin Oh  ;  Kyong Jin Park  ;  Taehyen Kim  ;  Yeon-Pyo Hong  ;  Yun-Jung Yang 
Citation
 ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, Vol.26(1) : 91, 2021-09 
Journal Title
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
ISSN
 1342-078X 
Issue Date
2021-09
Keywords
Bisphenol A ; Hepatic steatosis index ; Korean adults ; Korean national environmental health survey ; Nonalcoholic fatty liver disease
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is becoming a global health problem. Bisphenol A (BPA), one of most widely used environmental chemicals, is suspected to be a contributor to the development NAFLD. This study was performed to examine the relationship between human BPA levels and risk of NAFLD.

Methods: The data (n = 3476 adults: 1474 men and 2002 women) used in this study were obtained from the Korean National Environmental Health Survey III (2015-2017). BPA levels were measured in urine samples. NAFLD was defined using hepatic steatosis index after exclusion of other causes of hepatic diseases.

Results: There was a significant linear relationship between the elevated urinary BPA concentrations and risk of NAFLD. In a univariate analysis, odds ratio (OR) of the highest quartile of urinary BPA level was 1.47 [95% confidence interval (CI) 1.11-1.94] compared to the lowest quartile. After adjusted with covariates, the ORs for NAFLD in the third and fourth quartiles were 1.31 [95% CI 1.03-1.67] and 1.32 [95% CI 1.03-1.70], respectively.

Conclusions: Urinary BPA levels are positively associated with the risk of NAFLD in adults. Further experimental studies are needed to understand the molecular mechanisms of BPA on NAFLD prevalence.
Files in This Item:
T202104037.pdf Download
DOI
10.1186/s12199-021-01010-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Eun-Jung(양은정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185391
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