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Physical and Biological Characteristics of Particle Therapy for Oncologists

Authors
 Hwa Kyung Byun  ;  Min Cheol Han  ;  Kyungmi Yang  ;  Jin Sung Kim  ;  Gyu Sang Yoo  ;  Woong Sub Koom  ;  Yong Bae Kim 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.53(3) : 611-620, 2021-07 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2021-07
Keywords
Neoplasms ; Particle therapy ; Radiation injuries ; Radiotherapy
Abstract
Particle therapy is a promising and evolving modality of radiotherapy that can be used to treat tumors that are radioresistant to conventional photon beam radiotherapy. It has unique biological and physical advantages compared with conventional radiotherapy. The characteristic feature of particle therapy is the "Bragg peak," a steep and localized peak of dose, that enables precise delivery of the radiation dose to the tumor while effectively sparing normal organs. Especially, the charged particles (e.g., proton, helium, carbon) cause a high rate of energy loss along the track, thereby leading to high biological effectiveness, which makes particle therapy attractive. Using this property, the particle beam induces more severe DNA double-strand breaks than the photon beam, which is less influenced by the oxygen level. This review describes the general biological and physical aspects of particle therapy for oncologists, including non-radiation oncologists and beginners in the field.
Files in This Item:
T202104030.pdf Download
DOI
10.4143/crt.2021.066
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Kim, Jinsung(김진성) ORCID logo https://orcid.org/0000-0003-1415-6471
Byun, Hwa Kyung(변화경) ORCID logo https://orcid.org/0000-0002-8964-6275
Han, Min Cheol(한민철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185104
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