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Glutathione 주사에 의해 유발된 치명적인 천식발작 1예

Other Titles
 A case of glutathione-induced life-threatening asthma attack 
Authors
 박정환  ;  김태희  ;  강민석  ;  권도선  ;  변민광  ;  조재화  ;  김형중  ;  김재경  ;  박혜정 
Citation
 ALLERGY ASTHMA & RESPIRATORY DISEASE, Vol.8(2) : 89-91, 2020-04 
Journal Title
ALLERGY ASTHMA & RESPIRATORY DISEASE
ISSN
 2288-0402 
Issue Date
2020-04
Keywords
Glutathione ; Asthma ; Attack
Abstract
Baek-ok injection (glutathione) has been widely used antioxidant therapy to whiten and has antiaging effects in Korea. Glutathione is an enzyme which synthesizes leukotriene, then it can induce asthma attack theoretically; however, there have been few case reports concerning this therapy. In this report, we described a 41-year-old woman who developed glutathione-induced life-threatening asthma attack. She has asthma history controlled by an intermittent salbutamol inhaler. She developed general weakness and dyspnea right after glutathione injection, and injection was discontinued. Dyspnea was progressively aggravated, and she lost consciousness with shock. Cardiopulmonary resuscitation was started, and she arrived at the Emergency Department with wheezing, hypoxia, severe respiratory acidosis, and nonmeasurable blood pressure. Intubation and mechanical ventilation were started with intramuscular epinephrine/intravenous methylprednisolone injection and repeated salbutamol/ipratropium/budesonide inhalation. After 5 hours, extubation and spontaneous breathing were successful without wheezing. Next day, pulmonary function test showed moderate an obstructive airway disease pattern, and she was discharged with inhaled fluticasone/salmeterol, oral methylprednisolone, and montelukast. We can exclude anaphylaxis, because serum tryptase obtained at the Emergency Department was 0.0 mg/dL and the absence of skin lesions and angioedema at arrival. Baek-ok injection (glutathione) should be carefully performed in asthma patients.
Files in This Item:
T999202173.pdf Download
DOI
10.4168/aard.2020.8.2.89
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184931
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