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Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage

 Sungwon Kim  ;  Chan Joo Lee  ;  Kyunghwa Han  ;  Kye Ho Lee  ;  Hye-Jeong Lee  ;  Sungha Park 
 SCIENTIFIC REPORTS, Vol.11(1) : 17450, 2021-08 
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We aimed to determine the proper modified thresholds for detecting and weighting CAC scores at 100 kV through histogram matching in comparison with 120 kV as a standard reference. From the training set (680 participants), modified thresholds at 100 kV were obtained through histogram matching of calcium pixels to 120 kV. From the validation set (213 participants), a standard CAC score at 120 kV, and modified CAC score at 100 kV using modified thresholds were compare through the paired t test and the Bland-Altman plot. Agreement for risk categories (no, minimal, mild, moderate, and severe) was evaluated using kappa statistics. Radiation doses were also compared. For the validation set, there was no significant difference between standard (median, 18.7; IQR, 0.0-207.0) and modified (median, 17.3; IQR, 0.0-220.9) CAC scores (P = 0.689). A small bias was achieved (0.74) with 95% limits of agreement from - 52.35 to 53.83. Agreements for risk categories were excellent (κ = 0.994). The mean dose-length-product of 100-kV scanning (30.1 ± 0.8 mGy * cm) was significantly decreased compared to 120-kV scanning (42.9 ± 0.6 mGy * cm) (P < 0.001). Histogram-derived modified thresholds at 100 kV can enable accurate CAC scoring while reducing radiation exposure.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sungwon(김성원) ORCID logo https://orcid.org/0000-0001-5455-6926
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Kye Ho(이계호) ORCID logo https://orcid.org/0000-0001-5568-1833
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Han, Kyung Hwa(한경화)
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