60 121

Cited 0 times in

Effectiveness of Hepatocellular Carcinoma Surveillance and an Optimal Surveillance Interval: Nationwide Cohort of Korea

Authors
 Heejin Bae  ;  Sang Ah Lee  ;  Jong Won Choi  ;  Shin Hye Hwang  ;  Sumi Park  ;  Mi Suk Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.62(8) : 758-766, 2021-08 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2021-08
MeSH
Carcinoma, Hepatocellular* / diagnosis ; Carcinoma, Hepatocellular* / epidemiology ; Cohort Studies ; Humans ; Liver Neoplasms* / diagnosis ; Liver Neoplasms* / epidemiology ; Republic of Korea / epidemiology ; Retrospective Studies
Keywords
Hepatocellular carcinoma ; mortality ; surveillance
Abstract
Purpose: To assess associations between surveillance intervals in a national hepatocellular carcinoma (HCC) surveillance program and receiving curative treatment and mortality using nationwide cohort data for Korea.

Materials and methods: Using the National Health Insurance Service Database of Korea, we retrospectively identified 3201852 patients, the target population of the national HCC surveillance program, between 2008 and 2017. After exclusion, a total of 64674 HCC patients were divided based on surveillance intervals: never screened, ≤6 months (6M), 7-12 months (1Y), 13-24 months (2Y), and 25-36 months (3Y). Associations for surveillance interval with the chance to receive curative therapy and all-cause mortality were analyzed.

Results: The 6M group (51.9%) received curative therapy more often than the other groups (1Y, 48.3%; 2Y, 43.8%; 3Y, 41.3%; never screened, 34.5%). Odds ratio for receiving curative therapy among the other surveillance interval groups (1Y, 0.87; 2Y, 0.76; 3Y, 0.77; never screened, 0.57; p<0.001) were significantly lower than that of the 6M group. The hazard ratios (HRs) of all-cause mortality were 1.07, 1.14, and 1.37 for 2Y, 3Y, and never screened groups. The HR for the 1Y group (0.96; p=0.092) was not significantly different, and it was lower (0.91; p<0.001) than that of the 6M group after adjustment for lead-time bias. Curative therapy was associated with survival benefits (HR, 0.26; p<0.001).

Conclusion: HCC surveillance, especially at a surveillance interval of 6 months, increases the chance to receive curative therapy.
Files in This Item:
T202103838.pdf Download
DOI
10.3349/ymj.2021.62.8.758
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Bae, Heejin(배희진) ORCID logo https://orcid.org/0000-0002-1227-8646
Hwang, Shin Hye(황신혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184838
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links