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Reconstruction of Muscle Fascicle-Like Tissues by Anisotropic 3D Patterning

Authors
 Yoonhee Jin  ;  Eun Je Jeon  ;  Sohyeon Jeong  ;  Sungjin Min  ;  Yi Sun Choi  ;  So Hyun Kim  ;  Jung Seung Lee  ;  Jisoo Shin  ;  Ji Hea Yu  ;  Da-Hee Ahn  ;  Yun-Gon Kim  ;  Hee Seok Yang  ;  Taek Jin Kang  ;  Sung-Rae Cho  ;  Nakwon Choi  ;  Seung-Woo Cho 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.31(25) : 2006227, 2021-06 
Journal Title
ADVANCED FUNCTIONAL MATERIALS
ISSN
 1616-301X 
Issue Date
2021-06
Abstract
Tissue engineering of skeletal muscle has been proposed as a potential regenerative treatment for extensive muscle damage. In this regard, the highly organized structure of skeletal muscles makes the alignment of cells especially indispensable in muscle tissue engineering. However, achieving the desired alignment continues to prove challenging, particularly in 3D engineered tissue constructs. In this study, a biomimetic approach for the generation of functional skeletal muscle fascicle-like tissues by recapitulating 3D muscle-like cellular and extracellular organization, is demonstrated. Anisotropic 3D alignment of muscle extracellular matrix (MEM) nanofibrils capable of providing a pro-myogenic microenvironment by regulating the kinetics of fibrillogenesis in a stretchable elastomeric chip, is achieved. Reprogrammed muscle progenitor cells develop myofibers along the aligned MEM nanofibrils in a 3D configuration, culminating in the structural and functional maturation of skeletal muscle. The resultant 3D muscle fascicle-like constructs support de novo muscle regeneration and induce functional restoration of injured muscles in animal models inflicted with volumetric muscle loss and congenital muscular dystrophy. This study not only highlights the fundamental roles of the muscle–mimetic structural guidance cues for 3D muscle tissue engineering, but also unveils the clinical potential of artificial muscle constructs in regenerative medicine.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202006227
DOI
10.1002/adfm.202006227
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184815
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