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Association between Copper-Zinc Ratio in Hair and Neutrophil-Lymphocyte Ratio within the Context of a Normal White Blood Cell Count among Overweight or Obese Korean Individuals: A Pilot Study

Authors
 Sun Young Jeong  ;  Hyo Young Shim  ;  Yong Jae Lee  ;  Byoungjin Park 
Citation
 Korean Journal of Family Medicine (가정의학회지), Vol.42(3) : 240-244, 2021-05 
Journal Title
Korean Journal of Family Medicine(가정의학회지)
ISSN
 2005-6443 
Issue Date
2021-05
Keywords
Copper ; Hair Analysis ; Neutrophil–Lymphocyte Ratio ; Obesity ; Oxidative Stress ; Zinc
Abstract
Background: Obesity is considered a state of enhanced oxidative stress as well as chronic and low-grade inflammation. The copper-zinc ratio in obese individuals has been reported to reflect systemic oxidative stress and inflammatory status. We investigated whether the neutrophil-lymphocyte ratio is related to the copper-zinc ratio in hair, within the context of a normal white blood cell count among overweight or obese Korean individuals.

Methods: We included 56 participants aged older than 20 years who voluntarily sought weight reduction treatment and met the inclusion criterion of body mass index of 23 kg/m2 or greater. Intra-abdominal visceral adipose tissue was measured by computed tomography imaging, while the copper and zinc levels were measured by hair mineral analysis. Using multiple linear regression analysis, we examined the associations between the neutrophil-lymphocyte ratio and the copper-zinc ratio.

Results: The mean age, body mass index, and visceral adipose tissue were 46.0±10.5 years, 29.0±4.1 kg/cm2 , and 142.9±68.8 cm2 , respectively. Pearson's correlation analysis revealed the association of the neutrophil-lymphocyte ratio with copper level (r=0.475, P<0.001) and copper-zinc ratio (r=0.494, P<0.001). After adjusting for confounding variables, we found the neutrophil-lymphocyte ratio was significantly associated with the level of copper and the copper-zinc ratio in hair (regression coefficient: 0.055±0.015; P<0.001 and regression coefficient: 0.761±0.185; P<0.001, respectively).

Conclusion: A higher copper-zinc ratio in hair is positively and independently associated with the neutrophil-lymphocyte ratio. Thus, a high hair copper-zinc ratio could be a useful parameter for oxidative burden of individuals predisposed to obesity-related comorbidity.
Files in This Item:
T202103397.pdf Download
DOI
10.4082/kjfm.20.0018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184679
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