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Deferoxamine Reduces Inflammation and Osteoclastogenesis in Avulsed Teeth

Authors
 Ko Eun Lee  ;  Seunghan Mo  ;  Hyo-Seol Lee  ;  Mijeong Jeon  ;  Je Seon Song  ;  Hyung-Jun Choi  ;  Hyunsoo Cho  ;  Chung-Min Kang 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(15) : 8225, 2021-07 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Issue Date
2021-07
Keywords
bone biology ; bone remodeling/regeneration ; deferoxamine ; infection control ; inflammation ; osteoclast(s)
Abstract
Replacement and inflammatory resorption are serious complications associated with the delayed replantation of avulsed teeth. In this study, we aimed to assess whether deferoxamine (DFO) can suppress inflammation and osteoclastogenesis in vitro and attenuate inflammation and bone resorption in a replanted rat tooth model. Cell viability and inflammation were evaluated in RAW264.7 cells. Osteoclastogenesis was confirmed by tartrate-resistant acid phosphatase staining, reactive oxygen species (ROS) measurement, and quantitative reverse transcriptase-polymerase chain reaction in teeth exposed to different concentrations of DFO. In vivo, molars of 31 six-week-old male Sprague-Dawley rats were extracted and stored in saline (n = 10) or DFO solution (n = 21) before replantation. Micro-computed tomography (micro-CT) imaging and histological analysis were performed to evaluate inflammation and root and alveolar bone resorption. DFO downregulated the genes related to inflammation and osteoclastogenesis. DFO also reduced ROS production and regulated specific pathways. Furthermore, the results of the micro-CT and histological analyses provided evidence of the decrease in inflammation and hard tissue resorption in the DFO group. Overall, these results suggest that DFO reduces inflammation and osteoclastogenesis in a tooth replantation model, and thus, it has to be further investigated as a root surface treatment option for an avulsed tooth.
Files in This Item:
T202103296.pdf Download
DOI
10.3390/ijms22158225
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chung Min(강정민) ORCID logo https://orcid.org/0000-0001-7813-3741
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Lee, Koeun(이고은)
Jeon, Mi Jeong(전미정)
Cho, Hyunsoo(조현수) ORCID logo https://orcid.org/0000-0003-2651-6403
Choi, Hyung Jun(최형준) ORCID logo https://orcid.org/0000-0002-3315-6912
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184621
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