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Micro-computed tomography with contrast enhancement: An excellent technique for soft tissue examination in humans

 Jehoon O  ;  Hyun-Jin Kwon  ;  Tae-Hyeon Cho  ;  Seung Hoon Woo  ;  Yun-Hee Rhee  ;  Hun-Mu Yang 
 PLOS ONE, Vol.16(7) : e0254264, 2021-07 
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Manual dissection and histologic examination are commonly used to investigate human structures, but there are limitations in the damage caused to delicate structures or the provision of limited information. Micro-computed tomography (microCT) enables a three-dimensional volume-rendered observation of the sample without destruction and deformation, but it can only visualize hard tissues in general. Therefore, contrast-enhancing agents are needed to help in visualizing soft tissue. This study aimed to introduce microCT with phosphotungstic acid preparation (PTA-microCT) by applying the method to different types of human tissue. Specimens from human cadavers were used to examine the orbicularis retaining ligament (ORL), nasolabial fold (NLF), and the calcaneal tunnel of the sole. Using PTA-microCT, relevant information of human structures was identified. In the ORL study, tiny and delicate ligamentous fibers were visualized in detail with multidirectional continuity. In the NLF study, complex structural formation consisting of various types of soft tissue were investigated comprehensively. In the calcaneal tunnel study, the space surrounded by diverse features and its inner vulnerable structures were examined without damage. Consequently, we successfully applied the PTA-microCT technique to the analysis of specific human soft tissue structures that are challenging to analyze by conventional methods.
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1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyun-Jin(권현진) ORCID logo https://orcid.org/0000-0001-7752-6172
Yang, Hun Mu(양헌무) ORCID logo https://orcid.org/0000-0003-1954-0114
O, Jehoon(오제훈) ORCID logo https://orcid.org/0000-0003-4351-3183
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