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Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits

Authors
 Won Hyuk Chang  ;  Jungsoo Lee  ;  Yong-Il Shin  ;  Myoung-Hwan Ko  ;  Deog Young Kim  ;  Min Kyun Sohn  ;  Jinuk Kim  ;  Yun-Hee Kim 
Citation
 JOURNAL OF PERSONALIZED MEDICINE, Vol.11(6) : 545, 2021-06 
Journal Title
JOURNAL OF PERSONALIZED MEDICINE
Issue Date
2021-06
Keywords
Cerebrolysin ; functional imaging ; motor impairment ; motor recovery ; rehabilitation ; stroke
Abstract
The objective of this study was to evaluate whether Cerebrolysin combined with rehabilitation therapy supports additional motor recovery in stroke patients with severe motor impairment. This study analyzed the combined data from the two phase IV prospective, multicenter, randomized, double-blind, placebo-controlled trials. Stroke patients were included within seven days after stroke onset and were randomized to receive a 21-day treatment course of either Cerebrolysin or placebo with standardized rehabilitation therapy. Assessments were performed at baseline, immediately after the treatment course, and 90 days after stroke onset. The plasticity of the motor system was assessed by diffusion tensor imaging and resting state fMRI. In total, 110 stroke patients were included for the full analysis set (Cerebrolysin n = 59, placebo n = 51). Both groups showed significant motor recovery over time. Repeated-measures analysis of varianceshowed a significant interaction between time and type of intervention as measured by the Fugl-Meyer Assessment (p < 0.05). The Cerebrolysin group demonstrated less degenerative changes in the major motor-related white matter tracts over time than the placebo group. In conclusion, Cerebrolysin treatment as an add-on to a rehabilitation program is a promising pharmacologic approach that is worth considering in order to enhance motor recovery in ischemic stroke patients with severe motor impairment.
Files in This Item:
T202102915.pdf Download
DOI
10.3390/jpm11060545
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184354
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