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Effect of hepatic steatosis on native T1 mapping of 3T magnetic resonance imaging in the assessment of T1 values for patients with non-alcoholic fatty liver disease

Authors
 Jhii-Hyun Ahn  ;  Jeong-Sik Yu  ;  Kyu-Sang Park  ;  Seong Hee Kang  ;  Ji Hye Huh  ;  Jae Seung Chang  ;  Jong-Han Lee  ;  Moon Young Kim  ;  Marcel Dominik Nickel  ;  Stephan Kannengiesser  ;  Jang-Young Kim  ;  Sang-Baek Koh 
Citation
 MAGNETIC RESONANCE IMAGING, Vol.80 : 1-8, 2021-07 
Journal Title
MAGNETIC RESONANCE IMAGING
ISSN
 0730-725X 
Issue Date
2021-07
Keywords
Hepatic fibrosis ; Hepatic steatosis ; Liver stiffness ; Nonalcoholic fatty liver disease ; T1 mapping ; T1 value
Abstract
Purpose: This study investigated whether T1 values in native T1 mapping of 3T magnetic resonance imaging (MRI) of the liver were affected by the fatty component.

Methods: This prospective study involved 340 participants from a population-based cohort study between May 8, 2018 and August 8, 2019. Data obtained included: (1) hepatic stiffness according to magnetic resonance elastography (MRE); (2) T1 value according to T1 mapping; (3) fat fraction and iron concentration from multi-echo Dixon; and (4) clinical indices of hepatic steatosis including body mass index, waist circumference, history of diabetes, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, and triglycerides. The correlations between T1 value and fat fraction, and between T1 value and liver stiffness were assessed using Pearson's correlation coefficient. The independent two-sample t-test was used to evaluate the differences in T1 values according to the presence or absence of hepatic steatosis, and the one-way analysis of variance was used to evaluate the difference in T1 value by grading of hepatic steatosis according to MRI-based proton density fat fraction (PDFF). In addition, univariate and multivariate linear regression analyses were performed to determine whether other variables influenced the T1 value.

Results: T1 value showed a positive correlation with the fat fraction obtained from PDFF (r = 0.615, P < 0.001) and with the liver stiffness obtained from MRE (r = 0.370, P < 0.001). Regardless of the evaluation method, the T1 value was significantly increased in subjects with hepatic steatosis (P < 0.001). When comparing hepatic steatosis grades based on MRI-PDFF, the mean T1 values were significantly different in all grades, and the T1 value tended to increase as the grade increased (P < 0.001, P for trend <0.001). On multiple linear regression analysis, the T1 value was influenced by MRI-PDFF, calculated liver iron concentration, liver stiffness, and serum aspartate aminotransferase level.

Conclusion: The T1 value obtained by current T1 mapping of 3T MRI was affected by the liver fat component and several other factors such as liver stiffness, iron concentration, and inflammation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0730725X21000473
DOI
10.1016/j.mri.2021.03.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184353
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