0 39

Cited 0 times in

Association Between the Use of Hypnotics and the Risk of Alzheimer's Disease

Authors
 Wonjeong Jeong  ;  Jae Hong Joo  ;  Hyunkyu Kim  ;  Yun Kyung Kim  ;  Eun-Cheol Park  ;  Sung-In Jang 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.81(4) : 1381-1389, 2021-06 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2021-06
Abstract
Background: Hypnotics, including benzodiazepines, are extensively and inappropriately prescribed for older people to treat anxiety and sleep disorders, despite the adverse health outcomes associated with their use. Objective: This study aimed to examine the association of the use of long- and short-acting hypnotics with the risk of Alzheimer's disease. Methods: Data from 234,634 participants, derived from the Korean National Health Insurance Service National Sample Cohort from 2002 to 2013, were examined. Individuals over the age of 50 years were included in the study. The dependent variable was the risk of Alzheimer's disease. Hypnotics were categorized by the period of the prescription of benzodiazepines, i.e., either till the participants were diagnosed with Alzheimer's disease or the end of the study period (December 31, 2013). Cox regression model was built to analyze the association between variables. Results: Individuals who used long-acting hypnotics were found to have a higher risk of Alzheimer's disease than non-users. Moreover, among individuals with sleep disorders, those who used hypnotics had a higher risk of Alzheimer's disease than those who did not. Conclusion: This study identified an association between the use of hypnotics and the risk of Alzheimer's disease among South Korean middle-aged and older people.
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad201319
DOI
10.3233/JAD-201319
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Jang, Sung In(장성인) ORCID logo https://orcid.org/0000-0002-0760-2878
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184327
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links