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Association Between the Use of Hypnotics and the Risk of Alzheimer's Disease

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dc.contributor.author박은철-
dc.contributor.author장성인-
dc.contributor.author장성인-
dc.date.accessioned2021-09-29T01:21:44Z-
dc.date.available2021-09-29T01:21:44Z-
dc.date.issued2021-06-
dc.identifier.issn1387-2877-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184327-
dc.description.abstractBackground: Hypnotics, including benzodiazepines, are extensively and inappropriately prescribed for older people to treat anxiety and sleep disorders, despite the adverse health outcomes associated with their use. Objective: This study aimed to examine the association of the use of long- and short-acting hypnotics with the risk of Alzheimer's disease. Methods: Data from 234,634 participants, derived from the Korean National Health Insurance Service National Sample Cohort from 2002 to 2013, were examined. Individuals over the age of 50 years were included in the study. The dependent variable was the risk of Alzheimer's disease. Hypnotics were categorized by the period of the prescription of benzodiazepines, i.e., either till the participants were diagnosed with Alzheimer's disease or the end of the study period (December 31, 2013). Cox regression model was built to analyze the association between variables. Results: Individuals who used long-acting hypnotics were found to have a higher risk of Alzheimer's disease than non-users. Moreover, among individuals with sleep disorders, those who used hypnotics had a higher risk of Alzheimer's disease than those who did not. Conclusion: This study identified an association between the use of hypnotics and the risk of Alzheimer's disease among South Korean middle-aged and older people.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOS Press-
dc.relation.isPartOfJOURNAL OF ALZHEIMERS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation Between the Use of Hypnotics and the Risk of Alzheimer's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorWonjeong Jeong-
dc.contributor.googleauthorJae Hong Joo-
dc.contributor.googleauthorHyunkyu Kim-
dc.contributor.googleauthorYun Kyung Kim-
dc.contributor.googleauthorEun-Cheol Park-
dc.contributor.googleauthorSung-In Jang-
dc.identifier.doi10.3233/JAD-201319-
dc.contributor.localIdA01618-
dc.contributor.localIdA03439-
dc.contributor.localIdA03439-
dc.relation.journalcodeJ01231-
dc.identifier.eissn1875-8908-
dc.identifier.pmid34057146-
dc.identifier.urlhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad201319-
dc.contributor.alternativeNamePark, Eun-Chul-
dc.contributor.affiliatedAuthor박은철-
dc.contributor.affiliatedAuthor장성인-
dc.contributor.affiliatedAuthor장성인-
dc.citation.volume81-
dc.citation.number4-
dc.citation.startPage1381-
dc.citation.endPage1389-
dc.identifier.bibliographicCitationJOURNAL OF ALZHEIMERS DISEASE, Vol.81(4) : 1381-1389, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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