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Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix

Authors
 Jihyun Kim  ;  Kyoung-Mi Lee  ;  Seung Hwan Han  ;  Eun Ae Ko  ;  Dong Suk Yoon  ;  Ik Kyu Park  ;  Hang-Cheol Shin  ;  Kwang Hwan Park  ;  Jin Woo Lee 
Citation
 JOURNAL OF TISSUE ENGINEERING, Vol.12 : 2041731421999750, 2021-03 
Journal Title
JOURNAL OF TISSUE ENGINEERING
Issue Date
2021-03
Keywords
Impaired wound healing ; basic fibroblast growth factor ; dual-hyaluronate collagen dressing matrix ; epidermal growth factor ; stabilized growth factor
Abstract
Patients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors-stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing.
Files in This Item:
T202102731.pdf Download
DOI
10.1177/2041731421999750
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Hwan(박광환) ORCID logo https://orcid.org/0000-0002-2110-0559
Yoon, Dong Suk(윤동석) ORCID logo https://orcid.org/0000-0001-5945-5569
Lee, Kyoung Mi(이경미) ORCID logo https://orcid.org/0000-0002-9038-8162
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
Han, Seung Hwan(한승환) ORCID logo https://orcid.org/0000-0002-7975-6067
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184278
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