Cited 15 times in
Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix
DC Field | Value | Language |
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dc.contributor.author | 박광환 | - |
dc.contributor.author | 이진우 | - |
dc.contributor.author | 한승환 | - |
dc.contributor.author | 이경미 | - |
dc.contributor.author | 윤동석 | - |
dc.date.accessioned | 2021-09-29T01:16:01Z | - |
dc.date.available | 2021-09-29T01:16:01Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184278 | - |
dc.description.abstract | Patients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors-stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Sage | - |
dc.relation.isPartOf | JOURNAL OF TISSUE ENGINEERING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Jihyun Kim | - |
dc.contributor.googleauthor | Kyoung-Mi Lee | - |
dc.contributor.googleauthor | Seung Hwan Han | - |
dc.contributor.googleauthor | Eun Ae Ko | - |
dc.contributor.googleauthor | Dong Suk Yoon | - |
dc.contributor.googleauthor | Ik Kyu Park | - |
dc.contributor.googleauthor | Hang-Cheol Shin | - |
dc.contributor.googleauthor | Kwang Hwan Park | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.identifier.doi | 10.1177/2041731421999750 | - |
dc.contributor.localId | A01437 | - |
dc.contributor.localId | A03230 | - |
dc.contributor.localId | A04305 | - |
dc.relation.journalcode | J04010 | - |
dc.identifier.eissn | 2041-7314 | - |
dc.identifier.pmid | 33796249 | - |
dc.subject.keyword | Impaired wound healing | - |
dc.subject.keyword | basic fibroblast growth factor | - |
dc.subject.keyword | dual-hyaluronate collagen dressing matrix | - |
dc.subject.keyword | epidermal growth factor | - |
dc.subject.keyword | stabilized growth factor | - |
dc.contributor.alternativeName | Park, Kwang Hwan | - |
dc.contributor.affiliatedAuthor | 박광환 | - |
dc.contributor.affiliatedAuthor | 이진우 | - |
dc.contributor.affiliatedAuthor | 한승환 | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 2041731421999750 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TISSUE ENGINEERING, Vol.12 : 2041731421999750, 2021-03 | - |
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