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Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix

DC Field Value Language
dc.contributor.author박광환-
dc.contributor.author이진우-
dc.contributor.author한승환-
dc.contributor.author이경미-
dc.contributor.author윤동석-
dc.date.accessioned2021-09-29T01:16:01Z-
dc.date.available2021-09-29T01:16:01Z-
dc.date.issued2021-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184278-
dc.description.abstractPatients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors-stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherSage-
dc.relation.isPartOfJOURNAL OF TISSUE ENGINEERING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDevelopment of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorJihyun Kim-
dc.contributor.googleauthorKyoung-Mi Lee-
dc.contributor.googleauthorSeung Hwan Han-
dc.contributor.googleauthorEun Ae Ko-
dc.contributor.googleauthorDong Suk Yoon-
dc.contributor.googleauthorIk Kyu Park-
dc.contributor.googleauthorHang-Cheol Shin-
dc.contributor.googleauthorKwang Hwan Park-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.1177/2041731421999750-
dc.contributor.localIdA01437-
dc.contributor.localIdA03230-
dc.contributor.localIdA04305-
dc.relation.journalcodeJ04010-
dc.identifier.eissn2041-7314-
dc.identifier.pmid33796249-
dc.subject.keywordImpaired wound healing-
dc.subject.keywordbasic fibroblast growth factor-
dc.subject.keyworddual-hyaluronate collagen dressing matrix-
dc.subject.keywordepidermal growth factor-
dc.subject.keywordstabilized growth factor-
dc.contributor.alternativeNamePark, Kwang Hwan-
dc.contributor.affiliatedAuthor박광환-
dc.contributor.affiliatedAuthor이진우-
dc.contributor.affiliatedAuthor한승환-
dc.citation.volume12-
dc.citation.startPage2041731421999750-
dc.identifier.bibliographicCitationJOURNAL OF TISSUE ENGINEERING, Vol.12 : 2041731421999750, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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