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Ultrahigh-field cardiovascular magnetic resonance T1 and T2 mapping for the assessment of anthracycline-induced cardiotoxicity in rat models: validation against histopathologic changes

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dc.contributor.author김영진-
dc.contributor.author박철환-
dc.contributor.author이혜정-
dc.contributor.author최병욱-
dc.contributor.author허진-
dc.contributor.author홍유진-
dc.contributor.author한경화-
dc.contributor.author김판기-
dc.date.accessioned2021-09-29T01:11:12Z-
dc.date.available2021-09-29T01:11:12Z-
dc.date.issued2021-06-
dc.identifier.issn1097-6647-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184238-
dc.description.abstractBackground: Chemotherapy-induced cardiotoxicity is a well-recognized adverse effect of chemotherapy. Quantitative T1-mapping cardiovascular magnetic resonance (CMR) is useful for detecting subclinical myocardial changes in anthracycline-induced cardiotoxicity. The aim of the present study was to histopathologically validate the T1 and T2 mapping parameters for the evaluation of diffuse myocardial changes in rat models of cardiotoxicity. Methods: Rat models of cardiotoxicity were generated by injecting rats with doxorubicin (1 mg/kg, twice a week). CMR was performed with a 9.4 T ultrahigh-field scanner using cine, pre-T1, post-T1 and T2 mapping sequences to evaluate the left ventricular ejection fraction (LVEF), native T1, T2, and extracellular volume fraction (ECV). Histopathological examinations were performed and the association of histopathological changes with CMR parameters was assessed. Results: Five control rats and 36 doxorubicin-treated rats were included and classified into treatment periods. In the doxorubicin-treated rats, the LVEF significantly decreased after 12 weeks of treatment (control vs. 12-week treated: 73 ± 4% vs. 59 ± 9%, P = 0.01). Increased native T1 and ECV were observed after 6 weeks of treatment (control vs. 6-week treated: 1148 ± 58 ms, 14.3 ± 1% vs. 1320 ± 56 ms, 20.3 ± 3%; P = 0.005, < 0.05, respectively). T2 values also increased by six weeks of treatment (control vs. 6-week treated: 16.3 ± 2 ms vs. 10.3 ± 1 ms, P < 0.05). The main histopathological features were myocardial injury, interstitial fibrosis, inflammation, and edema. The mean vacuolar change (%), fibrosis (%), and inflammation score were significantly higher in 6-week treated rats than in the controls (P = 0.03, 0.03, 0.02, respectively). In the univariable analysis, vacuolar change showed the highest correlation with native T1 value (R = 0.60, P < 0.001), and fibrosis showed the highest correlation with ECV value (R = 0.78, P < 0.001). In the multiple linear regression analysis model, vacuolar change was a significant factor for change in native T1 (P = 0.01), and vacuolar change and fibrosis were significant factors for change in ECV (P = 0.006, P < 0.001, respectively) by adding other histopathological parameters (i.e., inflammation and edema scores) CONCLUSIONS: Quantitative T1 and T2 mapping CMR is a useful non-invasive tool reflecting subclinical histopathological changes in anthracycline-induced cardiotoxicity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfJOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleUltrahigh-field cardiovascular magnetic resonance T1 and T2 mapping for the assessment of anthracycline-induced cardiotoxicity in rat models: validation against histopathologic changes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHeae Surng Park-
dc.contributor.googleauthorYoo Jin Hong-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorPan Ki Kim-
dc.contributor.googleauthorEunkyung An-
dc.contributor.googleauthorJi Yeon Lee-
dc.contributor.googleauthorChul Hwan Park-
dc.contributor.googleauthorHye-Jeong Lee-
dc.contributor.googleauthorJin Hur-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorByoung Wook Choi-
dc.identifier.doi10.1186/s12968-021-00767-8-
dc.contributor.localIdA00727-
dc.contributor.localIdA01722-
dc.contributor.localIdA03320-
dc.contributor.localIdA04059-
dc.contributor.localIdA04370-
dc.contributor.localIdA04422-
dc.relation.journalcodeJ01294-
dc.identifier.eissn1532-429X-
dc.identifier.pmid34134713-
dc.subject.keywordCardiotoxicity-
dc.subject.keywordEdema-
dc.subject.keywordInflammation-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordMyocardial fibrosis-
dc.subject.keywordRats-
dc.subject.keywordT1 mapping-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.affiliatedAuthor김영진-
dc.contributor.affiliatedAuthor박철환-
dc.contributor.affiliatedAuthor이혜정-
dc.contributor.affiliatedAuthor최병욱-
dc.contributor.affiliatedAuthor허진-
dc.contributor.affiliatedAuthor홍유진-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage76-
dc.identifier.bibliographicCitationJOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol.23(1) : 76, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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