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Comparison of the effectiveness of Martin's equation, Friedewald's equation, and a Novel equation in low-density lipoprotein cholesterol estimation

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dc.contributor.author송유현-
dc.contributor.author이지원-
dc.contributor.author이혜선-
dc.contributor.author장혁재-
dc.contributor.author백수정-
dc.date.accessioned2021-09-29T01:08:24Z-
dc.date.available2021-09-29T01:08:24Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184215-
dc.description.abstractLow-density-lipoprotein cholesterol (LDL-C) is the main target in atherosclerotic cardiovascular disease (ASCVD). We aimed to validate and compare a new LDL-C estimation equation with other well-known equations. 177,111 samples were analysed from two contemporary population-based cohorts comprising asymptomatic Korean adults who underwent medical examinations. Performances of the Friedewald (FLDL), Martin (MLDL), and Sampson (SLDL) equations in estimating direct LDL-C by homogenous assay were assessed by measures of concordance (R2, RMSE, and mean absolute difference). Analyses were performed according to various triglyceride (TG) and/or LDL-C strata. Secondary analyses were conducted within dyslipidaemia populations of each database. MLDL was superior or at least similar to other equations regardless of TG/LDL-C, in both the general and dyslipidaemia populations (RMSE = 11.45/9.20 mg/dL; R2 = 0.88/0.91; vs FLDL: RMSE = 13.66/10.42 mg/dL; R2 = 0.82/0.89; vs SLDL: RMSE = 12.36/9.39 mg/dL; R2 = 0.85/0.91, per Gangnam Severance Hospital Check-up/Korea Initiatives on Coronary Artery Calcification data). MLDL had a slight advantage over SLDL with the lowest MADs across the full spectrum of TG levels, whether divided into severe hyper/non-hyper to moderate hypertriglyceridaemia samples or stratified by 100-mg/dL TG intervals, even up to TG values of 500-600 mg/dL. MLDL may be a readily adoptable and cost-effective alternative to direct LDL-C measurement, irrespective of dyslipidaemia status. In populations with relatively high prevalence of mild-to-moderate hypertriglyceridaemia, Martin's equation may be optimal for LDL-C and ASCVD risk estimation.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of the effectiveness of Martin's equation, Friedewald's equation, and a Novel equation in low-density lipoprotein cholesterol estimation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorYouhyun Song-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorSu Jung Baik-
dc.contributor.googleauthorSoyoung Jeon-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorSu-Yeon Choi-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorHae-Won Han-
dc.contributor.googleauthorSung Hak Park-
dc.contributor.googleauthorJidong Sung-
dc.contributor.googleauthorHae Ok Jung-
dc.contributor.googleauthorJi Won Lee-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1038/s41598-021-92625-x-
dc.contributor.localIdA05650-
dc.contributor.localIdA03203-
dc.contributor.localIdA03312-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34188076-
dc.contributor.alternativeNameSong, Youhyun-
dc.contributor.affiliatedAuthor송유현-
dc.contributor.affiliatedAuthor이지원-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage13545-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 13545, 2021-06-
Appears in Collections:
6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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