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Longitudinal Effect of Hemoglobin Concentration With Incident Ischemic Heart Disease According to Hepatic Steatosis Status Among Koreans

Authors
 Dong Hyuk Jung  ;  Yong Jae Lee  ;  Byoungjin Park 
Citation
 FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol.8 : 677040, 2021-05 
Journal Title
FRONTIERS IN CARDIOVASCULAR MEDICINE
Issue Date
2021-05
Keywords
cohort study ; extrahepatic complications ; hemoglobin ; hepatic steatosis ; ischemic heart disease ; risk factor
Abstract
Background: An increased hemoglobin (Hb) level may have detrimental effects on hepatic steatosis (HS) as well as cardiovascular disease (CVD). We investigated Hb's effect on incident ischemic heart disease (IHD) risk in the context of hepatic steatosis (HS). Methods: We assessed 17,521 non-diabetic participants and retrospectively screened for IHD using the Korea National Health Insurance data. High Hb was defined as Hb levels ≥16.3 g/dL in men and 13.9 g/dL in women (>75th percentile). The participants were divided into five groups: reference (group 1), mild HS only (group 2), mild HS and high Hb (group 3), severe HS only (group 4), and severe HS and high Hb (group 5). We assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over 50 months from the baseline survey. Results: During the follow-up period, 330 (1.9%) participants developed IHD (310 angina pectoris and 20 myocardial infarction). Compared with the reference group (group 1), the HRs for IHD were 1.04 (95% CI, 0.75-1.46) in group 2, 1.14 (95% CI, 0.70-1.85) in group 3, 1.58 (95% CI, 1.08-2.32) in group 4, and 1.79 (95% CI, 1.15-2.80) in group 5, after adjusting for IHD risk factors. Conclusions: We found the combined effect of HS and Hb levels on the incidence of IHD.
Files in This Item:
T202102269.pdf Download
DOI
10.3389/fcvm.2021.677040
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184123
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