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Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice

Authors
 Claus Aagaard  ;  Niels Peter Hell Knudsen  ;  Iben Sohn  ;  Angelo A Izzo  ;  Hongmin Kim  ;  Emma Holsey Kristiansen  ;  Thomas Lindenstrøm  ;  Else Marie Agger  ;  Michael Rasmussen  ;  Sung Jae Shin  ;  Ida Rosenkrands  ;  Peter Andersen  ;  Rasmus Mortensen 
Citation
 JOURNAL OF IMMUNOLOGY, Vol.205(8) : 2146-2155, 2020-10 
Journal Title
JOURNAL OF IMMUNOLOGY
ISSN
 0022-1767 
Issue Date
2020-10
MeSH
Animals ; Antigens, Bacterial / immunology* ; Cell Differentiation / immunology* ; Female ; Guinea Pigs ; Mice ; Mycobacterium bovis / immunology* ; Mycobacterium tuberculosis / immunology* ; T-Lymphocytes* / immunology ; T-Lymphocytes* / pathology ; Tuberculosis* / immunology ; Tuberculosis* / pathology ; Tuberculosis* / prevention & control ; Vaccination
Abstract
Despite the fact that the majority of people in tuberculosis (TB)-endemic areas are vaccinated with the Bacillus Calmette-Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis-specific (or "non-BCG") subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis-specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis-specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design.
Files in This Item:
T202007188.pdf Download
DOI
10.4049/jimmunol.2000563
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183872
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