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Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2021-09-29T00:29:55Z | - |
dc.date.available | 2021-09-29T00:29:55Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183872 | - |
dc.description.abstract | Despite the fact that the majority of people in tuberculosis (TB)-endemic areas are vaccinated with the Bacillus Calmette-Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis-specific (or "non-BCG") subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis-specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis-specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Bacterial / immunology* | - |
dc.subject.MESH | Cell Differentiation / immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mycobacterium bovis / immunology* | - |
dc.subject.MESH | Mycobacterium tuberculosis / immunology* | - |
dc.subject.MESH | T-Lymphocytes* / immunology | - |
dc.subject.MESH | T-Lymphocytes* / pathology | - |
dc.subject.MESH | Tuberculosis* / immunology | - |
dc.subject.MESH | Tuberculosis* / pathology | - |
dc.subject.MESH | Tuberculosis* / prevention & control | - |
dc.subject.MESH | Vaccination | - |
dc.title | Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Claus Aagaard | - |
dc.contributor.googleauthor | Niels Peter Hell Knudsen | - |
dc.contributor.googleauthor | Iben Sohn | - |
dc.contributor.googleauthor | Angelo A Izzo | - |
dc.contributor.googleauthor | Hongmin Kim | - |
dc.contributor.googleauthor | Emma Holsey Kristiansen | - |
dc.contributor.googleauthor | Thomas Lindenstrøm | - |
dc.contributor.googleauthor | Else Marie Agger | - |
dc.contributor.googleauthor | Michael Rasmussen | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Ida Rosenkrands | - |
dc.contributor.googleauthor | Peter Andersen | - |
dc.contributor.googleauthor | Rasmus Mortensen | - |
dc.identifier.doi | 10.4049/jimmunol.2000563 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 32887748 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | 신성재 | - |
dc.citation.volume | 205 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2146 | - |
dc.citation.endPage | 2155 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.205(8) : 2146-2155, 2020-10 | - |
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