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Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice

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dc.contributor.author신성재-
dc.date.accessioned2021-09-29T00:29:55Z-
dc.date.available2021-09-29T00:29:55Z-
dc.date.issued2020-10-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183872-
dc.description.abstractDespite the fact that the majority of people in tuberculosis (TB)-endemic areas are vaccinated with the Bacillus Calmette-Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis-specific (or "non-BCG") subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis-specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis-specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association of Immunologists-
dc.relation.isPartOfJOURNAL OF IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Bacterial / immunology*-
dc.subject.MESHCell Differentiation / immunology*-
dc.subject.MESHFemale-
dc.subject.MESHGuinea Pigs-
dc.subject.MESHMice-
dc.subject.MESHMycobacterium bovis / immunology*-
dc.subject.MESHMycobacterium tuberculosis / immunology*-
dc.subject.MESHT-Lymphocytes* / immunology-
dc.subject.MESHT-Lymphocytes* / pathology-
dc.subject.MESHTuberculosis* / immunology-
dc.subject.MESHTuberculosis* / pathology-
dc.subject.MESHTuberculosis* / prevention & control-
dc.subject.MESHVaccination-
dc.titleImmunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorClaus Aagaard-
dc.contributor.googleauthorNiels Peter Hell Knudsen-
dc.contributor.googleauthorIben Sohn-
dc.contributor.googleauthorAngelo A Izzo-
dc.contributor.googleauthorHongmin Kim-
dc.contributor.googleauthorEmma Holsey Kristiansen-
dc.contributor.googleauthorThomas Lindenstrøm-
dc.contributor.googleauthorElse Marie Agger-
dc.contributor.googleauthorMichael Rasmussen-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorIda Rosenkrands-
dc.contributor.googleauthorPeter Andersen-
dc.contributor.googleauthorRasmus Mortensen-
dc.identifier.doi10.4049/jimmunol.2000563-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ01450-
dc.identifier.eissn1550-6606-
dc.identifier.pmid32887748-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthor신성재-
dc.citation.volume205-
dc.citation.number8-
dc.citation.startPage2146-
dc.citation.endPage2155-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY, Vol.205(8) : 2146-2155, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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