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황연, 후박 및 구연산 혼합제재물에 의한 Streptococcus mutans의 증식 및 hydroxyapatite 비드 부착 억제효과

Other Titles
 Inhibitory Effect of a mixture of Coptidis Rhizoma, Magnoliae Cortex and citric acid on growth and adherence of Streptococcus mutans to hydroxyapatite bead 
Authors
 유윤정  ;  박용석  ;  곽월아  ;  윤준호  ;  민연숙  ;  권호근  ;  이승일 
Citation
 Journal of Korean Academy of Oral Health (대한구강보건학회지), Vol.20(2) : 259-270, 1996-06 
Journal Title
Journal of Korean Academy of Oral Health(대한구강보건학회지)
ISSN
 1225-388X 
Issue Date
1996-06
Keywords
황연 ; 후박 및 구연산 혼합제재물 ; Streptococcus mutans ; 항균작용
Abstract
Streptococcus mutans is an etiologic agent of dental caries and has been known to induce dental caries by the process of initial attachment, proliferation and acid production. For the prevention of dental caries which is caused by this process, extracts of natural products have recently been introduced. To investigate the possibility of using Coptidis Rhizoma and Magnoliae cortex which are natural products as anticariogenic agents, we isolated extracts from Coptidis Rhizoma and Magnoliae Cortex and investigated the inhibitory effect of these extracts on growth of S. mutans using agar diffusion method. And we made several mixtures of Coptidis Rhizoma, Magnoliae Cortex, citric acid and metaphosphate to reduce a bitter taste of Coptidis Rhizoma and Magnoliae Cortex and investigated as follows. After we selected a mixture which had high growth inhibitory activity against S.

mutans by agar diffusion method, we examined the effect of the selected mixture on the attachment of S. mutans to hydroxyapatitie beads and on the growth of S. mutans according to exposure time. A mixture of Coptidis Rhizoma, Magnoliae Cortex and citric acid which combined at 3: 4: 3 ratio presented wide growth inhibitory zone of S. mutans and inhibited the attachment of S. mutans to hydroxyapatite beads at 0.1 % concentration. 0.1 % mixture inhibited growth of S. mutans after 2 hour exposure and 0.5 % mixture inhibited growth of S. mutans after 30 minute exposure. In conclusion, a mixture of Coptidis Rhizoma, Magnoliae Cortex and citric acid turned out to be an effective anticariogenic agent because this mixture inhibited not only growth but also attachment of S. mutans which is the etiologic agent of dental caries.
Files in This Item:
T199602038.pdf Download
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho Keun(권호근)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183544
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