내독소로 유발시킨 섬유증식조직에서 아스코르빈산의 역할

Abstract

Ascorbic acid, which is toxic to retinal pigment epithelial cells in vitro, can stimulate fibrotic tissue formation. this study investigated the influence of ascorbic acid on endotoxin-induced fibrosis. Experimental vitreal fibrosis was induced in the rabbit by injecting endotoxin with or without ascorbic acid into the vitreous, and compared the degree of fibrosis. Inflammation induced by 1 g of endotoxin first appeared on day 1, remained on day3. On day 7, organized Membrane was developed. The striking decrease in ascorbic acid occurred after the intravitreal injection of endotoxin. In a series of experiment in which ascorbic acid were used, endotoxin produced less inflammatory response compared to the control. Rabbits which were injected 1 g of endotoxin (with or without ascorbic acid) had shown significant vitreal fibrosis. Even thought the high conentration of ascorbic acid can provide extacellular protection for the ocular tissue during ocular inflammation, It was not effective in preventing the formation of membrane