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사람 신경항원에 대한 단세포군 항체의 생산 및 특성 분석

Other Titles: Production and Characterization of Monoclonal Antibodies to Human Nerve Specific Antigen

Authors: 박주영 ; 신전수 ; 이경호 ; 고춘명

Citation: Journal of the Korean Society for Microbiology (대한미생물학회지), Vol.31(1) : 69-74, 1996-03

Journal Title: Journal of the Korean Society for Microbiology(대한미생물학회지)

ISSN: 0253-3162

Issue Date: 1996-03

Full Text: https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE01486739

DOI: Peripheral nerve damage is commonly observed in leprosy patients, but the pathogenic processes of nerve damage are still not well understood. In the present study, we produced monoclonal antibodies to protein components from human central nerve system (CNS) in an attempt to investigate the immunological mechanisms of nerve damage and to detect nerve antigen from sera in leprosy patients. Seven monoclonal antibodies (six were IgG1 and one was IgG2a in iso type) were produced; five antibodies were reactive with 38 kDa AND 43 kDa molecules from human CNS; other two antibodies were cross-reactive with human myelin basic protein and human muscle protein in ELISA. No antibody was reactive with rabbit peripheral nerve system protein. Although further evaluations of these antibodies are required to know the specific binding site of CNS protein and the reactivity to other tissue protein, this study suggests that the monoclonal antibodies may be useful in studying the immunological mechanisms of nerve damage in leprosy.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

Yonsei Authors: Shin, Jeon Soo(신전수) https://orcid.org/0000-0002-8294-3234

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/183123

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